The effect of cholesterol-enriched diet on the activity of some lysosomal enzymes in the liver and blood plasma of rabbits

Abstract

Abstract. White New Zealand male rabbits (n = 12) were fed by high-cholesterol diet for 7 weeks. The activity of some lysosomal enzymes in blood plasma and in the liver was determined. The cholesterol-enriched diet resulted a significant of AP, LL, BGAL and BGLU activity up increase in the blood plasma to 131 %, 186 %, 308 % and 184 % as compared with those in control group of animals (n = 10). In the liver a significant increase of EL activity to 189 %, NAG to 172% and BGAL to 196 % was observed. The activity of LAP and LL decreased significantly to 76 % and 60 % of the control level, respectively.