Research on the combined effects of traditional Chinese medicine compound Based on physical movement Theory

Abstract

Methamphetamine (METH) is a powerful psychostimulant. Chronic obsessive and compulsive usage of METH caused great harm to human health (physical and psychological) and social stability issues all over the world. Currently, no drugs have been used to treat and prevent METH addiction. Our previous studies demonstrated that Chinese medicine compound (JDYH) can inhibit METH-induced sensitization in mice. To investigate the combined effects of JDYH on physical movement in C57BL/6 male mice. In the experiment, mice chronic treatment with JDYH (14.12-56.48 g/kg) for 28-30 days, physical movement activity and body weight was measured. The body weight and physical movement have no change after being treated with low-dose (14.12 g/kg) and mid-dose (28.24 g/kg) of chronic treatment with JDYH. These results suggest that JDYH (14.12-28.24 g/kg) for 21days were not inhibit physical movement in mice.