Shenfouweikang Herbs Inhibit Dysplasia in Rat Chronic Atrophy Gastrititis Model

Abstract

Purpose: To explore the anti-proliferation effect of the Shenfouweikang in treatment of chronic atrophy gastrititis. Methods: Wistar rat was used as the experimental model. The rats were divided into three groups, one control and the two drug administration experimental groups. Animals in the two experimental groups received either Shenfouweikang or Dele granule over a 90-day period starting at the first day after drug administration. Animals received saline as controls. All the rats were sacrificed at 91 days after treatment. The anti-proliferation effect was assessed by two ways: (1) The weight was periodically measured during the life of the animals. (2) The morphological changes of gastric mucous were examined by pathology analysis. (3) The expression of heat shock protein 70 was detected by immunohistochemistry. Results: Compared with controls and Dele granular powder, the dysplasia in rat chronic atrophy gastrititis model was significantly inhibited and reversed in the Shenfouweikang decoction group. The expression of heat shock protein 70 was decreased after Shenfouweikang herbs treatment. Conclusion: Shenfouweikang herbs could produce anti-proliferation effect through reversing the dysplasia of chronic atrophy gastrititis through down-regulating the expression of heat shock protein 70.