Affiliation:
1. Hubei Normal University
Abstract
An efficient method is described for the synthesis of 2-methoxy-thieno[2,3-d]pyrimidin- 4(3H)-one (5) via Gewald reaction, a tandem aza-Wittig reaction and cyclization process. The key step is an aza-Wittig reaction between iminophosphorane (2), 4-chlorophenyl isocyanine and nucleophilic reagent CH3OH. Its structures were determined by means of MS, IR and 1H NMR spectra.
Publisher
Trans Tech Publications, Ltd.