Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance-Reference-Cited by-同舟云学术

Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance

Published:2010-10-25 Issue:22 Volume:53 Page:8116-8128
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gangjee Aleem¹,Zhao Ying¹,Lin Lu¹,Raghavan Sudhir¹,Roberts Elizabeth G.²,Risinger April L.²,Hamel Ernest³,Mooberry Susan L.²

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States

2. Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, United States

3. Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101010n

Reference59 articles.

1. Microtubules as a target for anticancer drugs

2. How Do Microtubule-Targeted Drugs Work? An Overview

3. Refined structure of αβ-tubulin at 3.5 Å resolution 1 1Edited by I. A. Wilson

4. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites

Cited by 65 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Developments of Pyrrolo[2,3-d]pyrimidines with Pharmaceutical Potential;Current Organic Chemistry;2024-09

2. Novel Brain-Penetrant, Small-Molecule Tubulin Destabilizers for the Treatment of Glioblastoma;Biomedicines;2024-02-09

3. Verubulin (Azixa) Analogues with Increased Saturation: Synthesis, SAR and Encapsulation in Biocompatible Nanocontainers Based on Ca2+ or Mg2+ Cross-Linked Alginate;Pharmaceuticals;2023-10-21

4. Acetamidine in heterocycle synthesis;Synthetic Communications;2023-03-20

5. Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site;Bioorganic & Medicinal Chemistry;2023-03