Affiliation:
1. Marcotech oHG
2. Westphalian Wilhelms University Muenster
3. OOO NPK Medbiopharm
Abstract
The novel radio-protective drug 9-phenyl symm octahydro selenoxanthene is insoluble in water. The complexation with hydroxypropyl beta-cyclodextrin increases the water solubility improving the bioavailability. The stoichiometry of the supramolecular host-guest complex was studied by displacement experiments using fluorescence spectroscopy. With respect to the application in the radiologic brachy therapy the inclusion complex was encapsulated by spray drying with both, poly D,L-lactic-co-glycolic acid and gelatin. The in-vitro irradiation tests of the final ointment formulation show the inhibition of neoplasm development, and an efficient protection effect against radiation.
Publisher
Trans Tech Publications, Ltd.
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2 articles.
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