Effect of the clathrate complex of selenopyran and β-cyclodextrin on the rate of healing of a conditionally aseptic full-thickness planar wound in rats-Reference-Cited by-同舟云学术

Effect of the clathrate complex of selenopyran and β-cyclodextrin on the rate of healing of a conditionally aseptic full-thickness planar wound in rats

Published:2021-12-25 Issue:4 Volume:10 Page:166-170
ISSN:2658-5049
Container-title:Drug development & registration
language:
Short-container-title:Razrabotka i registraciâ lekarstvennyh sredstv

Author:

Zayats D. V.¹^ORCID,Buyklinskaya O. V.²^ORCID,Fedotova Ju. R.³^ORCID,Felenko N. S.⁴^ORCID

Affiliation:

1. "PHARMA-SEVER" CJSC

2. Saint Petersburg State Chemical and Pharmaceutical University

3. "Aquamarin" LLC

4. Nothern State Medical University

Abstract

Introduction. Selenopyran is an organic selenium compound with sharply hydrophobic properties. An increase in solubility in water (and as a consequence – and bioavailability) is possible due to the formation of inclusion complexes with cyclodextrins.Aim. The aim of this work was to study the effect of a gel containing a clathrate complex of selenopyran with β-cyclodextrin on the rate of wound healing on a model of a conditionally aseptic full-thickness planar wound in rats.Materials and methods. The object of the study was a gel containing a clathrate complex of selenopyran with β-cyclodextrin (the content of selenopyran in the gel was 0.1 %). A model of a full-thickness planar wound in sexually mature male rats was used. 20 individuals were divided into 2 groups – intact (without treatment) and experimental (received gel treatment). Efficacy was assessed by the change in wound area at 3, 5, 7, 9, 11 and 14 days after application of wound.Results and discussion. The results of the study showed that the relative area of the wounds in the treated animals by the 3rd day of the experiment was less than in the intact ones. On the fifth day of the experiment, the differences were statistically significant (57.49 ± 12.51 % in treated animals versus 85.27 ± 26.61 % in intact animals). By the 14th day of the experiment, there were practically no differences in the groups of animals.Conclusion. The results obtained indicate that when using a gel containing selenopyran in combination with β-cyclodextrin, it accelerates the transition from the inflammation phase to the proliferation phase. This is most likely due to the antioxidant properties of selenopyran. Considering the lower concentration of selenopyran in comparison with the therapeutic concentrations of other antioxidants (taurine, allantoin), it can be considered as a promising wound healing agent for further study.

Publisher

Center of Pharmaceutical Analytics Ltd

Subject

Drug Discovery,Pharmaceutical Science

Reference12 articles.

1. Galochkin V. A., Galochkina V. P. Organic and mineral forms of selenium, their metabolism, bioavailability and role in the body. Selskohozaystvennaya biologia = Agricultural Вiology. 2011;(4):3–15. (In Russ.)

2. Heinrich L. A., Pajaziti B., Roziev R. Drug delivery system of a radio-protective inclusion complex. Advanced Materials Research. 2014;(872):231–236. DOI: 10.4028/www.scientific.net/AMR.872.231.

3. Izmestyeva O. S., Erimbetov K. T., Bondarenko E. V., Goncharova A. Ya., Zhavoronkov L. P., Ivanov V. L., Chibisova O. F. Experimental evaluation of the adjuvant properties of 9-phenyl-symoctahydroselno- xstanten in radiotherapy. Radiatsionnaya biologia. Radioecologiya = Radiation biology. Radioecology. 2017;(4):391–398. (In Russ.) DOI: 10.7868/S0869803117040051.

4. Nikulina A. V., Sereda N. V. Scientific substantiation of the appointment of young productive animals of bioactive additives in a selenium- deficient region. Vestnik Orenburgskogo gosudarstvennogo universiteta = Vestnik of the Orenburg State University. 2016;(10):69–73. (In Russ.)

5. Bekker G. V., Kuksyonok V. Yu., Shtrykova V. V. Uvelichenie vodorastvorimosti preparata «Galodif» pri pomoshhi sozdanija kompleksov vkljuchenija s beta-ciklodekstrinom. Himija i himicheskaja tehnologija v XXI veke: materialy XXI Mezhdunarodnoj nauchnoprakticheskoj konferencii studentov i molodyh uchenyh imeni vydajushhihsja himikov L. P. Kuljova i N. M. Kizhnera, posvjashhennoj 110-letiju so dnja rozhdenija professora A. G Stromberga [Increasing the water solubility of the "Galodif" preparation by creating inclusion complexes with beta-cyclodextrin. Chemistry and chemical technology in the XXI century: materials of the XXI International scientific-practical conference of students and young scientists named after outstanding chemists L. P. Kulev and N. M. Kizhner, dedicated to the 110th anniversary of the birth of Professor A. G. Stromberg]. September 21–24, 2020; Tomsk: Tomsk Polytechnic University; 2020. P. 302–303. (In Russ.)