Affiliation:
1. Laboratory for Experimental Pharmacology
2. University of Belgrade
3. Faculty of Chemistry
Abstract
Cytotoxic activity of four series of coordinated complexes of Zn(II) and Fe(II) with hydrazone/hydrazide ligands against HeLa and B16 cells was evaluated. The ligands N’,N'2- bis[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H2L1) and N’,N'2-bis[(1E)-1-(2-pyridyl) ethylidene]propanedihydrazide (H2L2) and their Zn(II) complexes showed IC50 values in the low micromolar range, while the other ligands and complexes were less active or inactive.
Publisher
Trans Tech Publications, Ltd.
Subject
Mechanical Engineering,Mechanics of Materials,Condensed Matter Physics,General Materials Science
Cited by
8 articles.
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1. A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt(II), Zn(II), Cu(II), and Co(III) Complexes withN-heteroaromatic Schiff Base (E)-2-[N′-(1-pyridin-2-yl-ethylidene)hydrazino]acetate;Journal of Biochemical and Molecular Toxicology;2013-12-03
2. Evaluation of DNA-binding, radical scavenging and cytotoxic activity of five coordinated Cd(ii) complexes containing 2-acetylpyridine-N4-substituted thiosemicarbazone;RSC Advances;2013
3. Synthesis and structure of a Ni(II) complex with N′,N′ 2-bis[(1E)-1-(2-quinolyl)methylene]propanedihydrazide: multiple intramolecular CH ··· π interactions between quinoline and quinolineimine chelate;Journal of Coordination Chemistry;2012-02-07
4. Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide;Journal of Inorganic Biochemistry;2011-09
5. A comparative study of DNA binding and cell cycle phase perturbation by the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide N′,N′2-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide;Journal of Biochemical and Molecular Toxicology;2010-11-15