Electrospun Ketoprofen Sustained Release Nanofibers Prepared Using Coaxial Electrospinning

Author:

Yu Deng Guang1,Hu Min Hao1,Zhou Wen1,Chen Bi Yu1,Wang Xia1

Affiliation:

1. University of Shanghai for Science and Technology

Abstract

The present study investigates the preparation of sustained release drug-loaded nanofibers using a modified coaxial electrospinning process where only solvent is exploited as sheath fluid. Drug-loaded ethyl cellulose (EC) nanofibers are successfully generated smoothly and continuously without any clogging through the coaxial process, in which ethanol is used as sheath fluid and EC and ketoprofen (KET) are taken as the filament-forming matrix and active pharmaceutical ingredient, respectively. Field-emission scanning electron microscopic observations demonstrated that the nanofibers diameter can be manipulated through the sheath fluid flow rate. The composite nanofibers are in essential a molecular solid dispersion of EC and KET based on the hydrogen bonding between them, as verified by XRD and ATR-FTIR results. In vitro dissolution tests show that KET in the nanofibers has a fine sustained release profile via a typical Fickian diffusion mechanism. The modified coaxial electrospinning with solvent as sheath fluid can be a useful tool for developing novel sustained release drug delivery nanofibers.

Publisher

Trans Tech Publications, Ltd.

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