Affiliation:
1. Harbin Institute of Technology
Abstract
In the present study, we investigated the protective effect of anthocyanin extract from Lonicera caerulea var. edulis (LCA) on UVC-induced lipid and protein peroxidation using lecithin and Bull Serum Albumin (BSA) in vitro model. We also investigated the protective effect of anthocyanin on UVC induced cell injury in Spleen lymphocytes of mouse via MTT and comet assays. Peroxidation of lecithin and BSA generated by exposure to UVC radiation was significantly decreased by addition with various concentrations of LCA. Moreover, LCA exhibited an inhibitory effect on DNA damage induced by UVC radiation when compared with the control group, the DNA damage decrease at the LCA concentration of 50-200ug/ml, in comet assay. These results indicate that LCA has certain protective effect to ultraviolet radiation damage.
Publisher
Trans Tech Publications, Ltd.
Reference20 articles.
1. ZHOU Meijuan, ZHENG Li, GUO Ling, et al. Cell Biological Effect and Mechanism of Ultraviolet Radiation [J]. ACTA BIOPHYSICA SINICA 2010, 26(11): 950-958.
2. Ting WW, Vest CD, Sontheimer R. Practical and experimental consideration of sun protection in dermatology. Int J Dermatol, 2003, 42(7): 505~513.
3. Tsuda, T., Shiga, K., Ohshima, K., Kuwakishi, S. and Osuwu, T. Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseoks vulgaris L. Biochemi. Pharma, 1996. 52, 1033-1039.
4. Jin-Ming Konga, Lian-Sai Chiaa, Ngoh-Khang Goha, et al. Analysis and biological activities of anthocyanins. Phytochemistry, 2003, 64 (9): 923–933.
5. Q. Du, J. Zheng, Y. Xu, Composition of anthocyanins in mulberry and their antioxidant activity, Journal of Food Composition and Analysis, 2008, 21 (5): 390– 395.
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1 articles.
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