Affiliation:
1. Bandung Institute of Technology (ITB)
2. Indonesian Institute of Sciences (LIPI)
Abstract
Electrospinning is a simple versatile process to produce nanofibers. However, it requires careful approach to form appropriates fibers for different purposes. This report describes aspects influencing successful development of nanofiber containing BSA using electrospinning method. Optical and scanning electron microscopy, energy dispersive X-Ray and Fourier transformed infrared spectroscopy, differential scanning calorimetric, and X-Ray diffraction analysis of nanofiber were performed. Modification of PVA/BSA nanofiber with Eudragit L-100 was conducted by dip coating method. The presence of BSA increased the diameter of the fibers. Modification of PVA/BSA nanofiber with Eudragit L-100 delayed the release of BSA in acidic medium but promoting its release in intestinal mimicking medium.
Publisher
Trans Tech Publications, Ltd.
Reference26 articles.
1. T.J. Sill, H.A. von Recum, Electrospinning: Applications in Drug Delivery and Tissue Engineering, Biomater. 29 (2008) 1989-(2006).
2. A. Agarwal, J.H. Wendorff, A. Greiner, Use of Electrospinning Technique for Biomedical Applications, Polym. 49 (2008) 5603-5621.
3. A. Akhgari, Z. Heshmati, B.S. Makhmalzade, Indomethacin electrospun nanofibers for colonic drug delivery: preparation and characterization, Adv. Pharmaceut. Bull.; 3 (2013) 85-90.
4. T. Okuda, K. Tominaga, J. Kidoaki, Time-programmed dual release formulation by multilayered drug-loaded nanofiber meshes, Control. Release. 143 (2010) 258-264.
5. S. Sahoo, L.T. Ang, J.C.H. Goh, S.L. Toh, Growth Factor Delivery through Electrospun Nanofiber in Scaffold for Tissue Engineering Applications, J. Biomed. Mater. Res. A. 93 (2009) 1539-1550.
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献