Pancreatic Islet Culture and Preservation Strategies: Advances, Challenges, and Future Outlook-Reference-Cited by-同舟云学术

Pancreatic Islet Culture and Preservation Strategies: Advances, Challenges, and Future Outlook

Published:2010-12 Issue:12 Volume:19 Page:1523-1535
ISSN:0963-6897
Container-title:Cell Transplantation
language:en
Short-container-title:Cell Transplant

Author:

Daoud Jamal¹,Rosenberg Lawrence²,Tabrizian Maryam¹

Affiliation:

1. Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, QC, Canada

2. Department of Surgery, Faculty of Medicine, McGill University, Montreal, QC, Canada

Abstract

Postisolation islet survival is a critical step for achieving successful and efficient islet transplantation. This involves the optimization of islet culture in order to prolong survival and functionality in vitro. Many studies have focused on different strategies to culture pancreatic islets in vitro through manipulation of culture media, surface modified substrates, and the use of various techniques such as encapsulation, embedding, scaffold, and bioreactor culture strategies. This review aims to present and discuss the different methodologies employed to optimize pancreatic islet culture in vitro as well as address their respective advantages and drawbacks.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

Link

http://journals.sagepub.com/doi/pdf/10.3727/096368910X515872

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