Integrin Linked Kinase (ILK) and its Role in Liver Pathobiology

Author:

Martucci Nicole1,Michalopoulos George K.1,Mars Wendy M.1

Affiliation:

1. Department of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA

Abstract

Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the body. It binds to intracellular integrins to help promote signaling related to cell adhesion, apoptosis, proliferation, migration, and a plethora of other common cellular functions. In this review, ILKs role in the liver is detailed. Studies have shown ILK to be a major participant in hepatic ECM organization, liver regeneration, insulin resistance, and hepatocellular carcinoma.

Publisher

Cognizant, LLC

Subject

Genetics,Molecular Biology

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