REMEMProt: a resource of membrane-enriched proteome profiles, their disease associations, and biomarker status

Author:

Aravind Anjana1,Nandakumar Revathy1ORCID,Ahmed Mukhtar2,Nisar Mahammad3,Palollathil Akhina1,Kanichery Anagha1ORCID,Sreelan Sourav34ORCID,Sinan KP Munavvar34,Balaya Rex Devasahayam Arokia3,Vijayakumar Manavalan5,Prasad Thottethodi Subrahmanya Keshava1,Raju Rajesh13ORCID

Affiliation:

1. Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India

2. Department of Zoology, College of Science, King Saud University

3. Centre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore, India

4. Yenepoya Institute of Technology, Yenepoya (Deemed to be University), Mangalore, India

5. Department of Surgical Oncology, Yenepoya Medical College, Yenepoya (Deemed to be University), Mangalore, India

Abstract

The differential expression of plasma membrane proteins is integrally analyzed for their diagnosis, prognosis, and therapeutic applications in diverse clinical manifestations. Necessarily, distinct membrane protein enrichment methods and mass spectrometry platforms are employed for their global and relative quantitation. First of its kind to explore, we compiled membrane-associated proteomes in human and mouse systems into a database named, Resource of Experimental Membrane-Enriched Mass spectrometry–derived Proteome (REMEMProt). It currently hosts 14,626 proteins (9,507 proteins inHomo sapiens; 5,119 proteins inMus musculus) with information on their membrane-protein enrichment methods, experimental/physiological context of detection in cells or tissues, transmembrane domain analysis, and their current attribution as biomarkers. Based on these annotations and the transmembrane domain analysis in proteins or their binary/complex protein–protein interactors, REMEMProt facilitates the assessment of the plasma membrane localization potential of proteins through batch query. A cross-study enrichment analysis platform is enabled in REMEMProt for comparative analysis of proteomes using novel/modified membrane enrichment methods and evaluation of methods for targeted enrichment of membrane proteins. REMEMProt data are made freely accessible to explore and download athttps://rememprot.ciods.in/.

Funder

King Saud University

Publisher

Life Science Alliance, LLC

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