Clinical and cytogenetic analysis of an intracranial inflammatory myofibroblastic tumor induced by a ventriculoperitoneal shunt

Author:

de Oliveira Ricardo Santos1,Amato Marcelo Campos Moraes1,Brassesco María Sol2,Valera Elvis Terci2,Jucá Carlos Eduardo Barros1,Neder Luciano3,Tone Luiz Gonzaga2,Machado Hélio Rubens1

Affiliation:

1. Division of Pediatric Neurosurgery, Department of Surgery and Anatomy;

2. Division of Pediatric Oncology, Department of Pediatrics; and

3. Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil

Abstract

The authors report the first case of an intracranial inflammatory myofibroblastic tumor (IMT) associated with the placement of a ventriculoperitoneal shunt, which occurred in a 7-year-old boy. Neuroradiological features showed a mass surrounding the ventricular catheter. The lesion was completely resected. Histological study revealed the mass to be an IMT. The patient's postoperative course was complicated by a local recurrence requiring a second surgery. Cytogenetic analysis of the sample by comparative genome hybridization revealed several chromosomal amplifications and regional losses. The occurrence of IMT in the CNS has rarely been reported. For treatment of this condition, the authors recommend a total removal of the shunt with a mass excision to prevent local recurrence.

Publisher

Journal of Neurosurgery Publishing Group (JNSPG)

Subject

General Medicine

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