Role of prostaglandin F2 in human cerebral vasospasm

Abstract

✓Prostaglandin (PGF2α) concentrations were measured by radioimmunoassay in serial samples of CSF from patients with subarachnoid hemorrhage, in an attempt to correlate these values with the presence or degree of the arterial spasm. Although elevated concentrations of PGF2α were found in most of these patients, when compared with a control series, there was no correlation between these values and the appearance of cerebral vasospasm. The results are discussed with reference to previous experimental work suggesting a role of PGF2α in the pathogenesis of cerebral vasospasm.