SIMPLE DESIGN OF MINIATURIZED CABINET FOR COMPOUNDING VITAMIN C EFFERVESCENT TABLET IN LABORATORY SCALE

Abstract

Objective: The aim of this study was to design miniaturized cabinet that needs the tight requirements in formulating the ingredients of the effervescent tablets to minimize the relative humidity value in order to prevent the initial effervescent reaction.Methods: The compounding workspace was created by designing cabinet arranged with special equipment so that the humidity and temperature of the mixing chamber could be monitored. The conditioning of the workspace was carried out using a variety of methods ie lights, active silica gel and a combination of both during certain observation times. In this study, all of the components in the effervescent tablet formula were mixed using two steps of the wet granulation method. The evaluation of effervescent tablets included: the appearance of the tablet, diameter, tablet thickness, weight uniformity, hardness, friability, tablet disintegration time, pH of the solution, and hedonic test.Results: The results of moisture control optimization indicated that the most rapid method of lowering moisture was using a combination of active light and silica gel. After 100 min, this method could decreased the relative humidity (RH) by 0.415% per min. Based on the evaluation results, all formulas achieved the requirements of good effervescent tablets.Conclusion: In this research, the design of compounding cabinets with dimensions of 60x40x59.5 cm was proven to produce effervescent tablets that fulfill the requirements.