OXIDATIVE STRESS IN ACNE VULGARIS

Abstract

Objective: Acne vulgaris is a common dermatological disease characterized by sebaceous hyperplasia, follicular hyperkeratinization, Immune reactions, and Inflammation. Our study aims to determine the role of oxidative stress in the pathogenesis of acne vulgaris. Methods: 35 acne patients and 35 healthy people were selected and their serum levels of superoxide dismutase SOD and Malondialdehyde MDA were estimated and the results are compared with the control group. Also, the relationship between the duration and severity of acne with the parameters is assessed. Results: The activity of SOD is found to be decreased and the level of MDA is found to be increased in acne patients compared to healthy people, suggesting increased oxidative stress in Acne vulgaris patients. Conclusion: Our study concludes that oxidative stress plays a role in the pathogenesis of Acne vulgaris and antioxidants can be used as a part of treatment.