Affiliation:
1. From the Department of Pathology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19174
Abstract
The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse µ-chain antibody and goat antimouse γ1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by the clonal progeny of a single precursor cell.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
44 articles.
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