Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets.-Reference-Cited by-同舟云学术

Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets.

Published:1988-02-01 Issue:2 Volume:167 Page:345-352
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Lanzavecchia A¹,Abrignani S¹,Scheidegger D¹,Obrist R¹,Dörken B¹,Moldenhauer G¹

Affiliation:

1. Basel Institute for Immunology, Switzerland.

Abstract

We found that three tumor patients treated with mouse mAbs have T cells that recognize processed mouse Ig on autologous APC in a class II-restricted fashion, and we have shown that mouse mAbs directed against various cell surface molecules can be used as antigens to focus these T cells on an MHC class II-positive target of choice.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/167/2/345/1097821/345.pdf

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