FcγRIII (CD16) equips immature 6-sulfo LacNAc–expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens-Reference-Cited by-同舟云学术

FcγRIII (CD16) equips immature 6-sulfo LacNAc–expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens

Published:2013-05-02 Issue:18 Volume:121 Page:3609-3618
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Döbel Thomas¹,Kunze Anja¹,Babatz Jana²,Tränkner Katja²,Ludwig Andreas³,Schmitz Marc²,Enk Alexander¹,Schäkel Knut¹

Affiliation:

1. Department of Dermatology, Heidelberg University Hospital, Heidelberg, Germany;

2. Institute of Immunology, Technical University Dresden, Dresden, Germany; and

3. Institute of Pharmacology and Toxicology and Interdisciplinary Center for Clinical Research, RWTH Aachen University, Aachen, Germany

Abstract

Key Points The expression of CD16 by immature slanDCs equips these cells with a unique capacity to handle immune complexes. CD16 expression on slanDCs is rapidly downregulated during maturation by activation of ADAM10 and ADAM17.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/18/3609/1362976/3609.pdf

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4. CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions.;Matsui;J Immunol,2009

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