Immunodominant antibody germlines in COVID-19-Reference-Cited by-同舟云学术

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Immunodominant antibody germlines in COVID-19

Published:2021-03-03 Issue:5 Volume:218 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Andreano Emanuele¹^ORCID,Rappuoli Rino¹²^ORCID

Affiliation:

1. Monoclonal Antibody Discovery Lab, Fondazione Toscana Life Sciences, Siena, Italy

2. Faculty of Medicine, Imperial College, London, UK

Abstract

The neutralizing antibody response to SARS-CoV-2 is dominated by antibodies deriving from germlines IGHV3-53/IGHV3-66, which are also associated with self-reacting antibodies. Could vaccines avoid the expansion of this immunodominant response, decrease the risk of autoimmunity, and still protect against emerging SARS-CoV-2 variants?

Funder

European Research Council

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/doi/10.1084/jem.20210281/1411035/jem_20210281.pdf

Reference19 articles.

1. SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

2. Autoantibodies against type I IFNs in patients with life-threatening COVID-19

3. Data, disease and diplomacy: GISAID's innovative contribution to global health

4. Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antigenic sin and multiple breakthrough infections drive converging evolution of COVID-19 neutralizing responses;Cell Reports;2024-09

2. SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines;Science Immunology;2024-08-09

3. Diversification of the VH3‐53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS‐CoV‐2 virus variants;European Journal of Immunology;2024-04-09

4. B cell maturation restored ancestral germlines to control Omicron BA.2.86;2024-03-04

5. Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation;Journal of Infection;2024-01

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