Autoantibodies against type I IFNs in patients with life-threatening COVID-19-Reference-Cited by-全球学者库

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Published:2020-10-23 Issue:6515 Volume:370 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bastard Paul¹²³^ORCID,Rosen Lindsey B.⁴^ORCID,Zhang Qian³^ORCID,Michailidis Eleftherios⁵^ORCID,Hoffmann Hans-Heinrich⁵^ORCID,Zhang Yu⁴,Dorgham Karim⁶^ORCID,Philippot Quentin¹²,Rosain Jérémie¹²,Béziat Vivien¹²³^ORCID,Manry Jérémy¹²^ORCID,Shaw Elana⁴^ORCID,Haljasmägi Liis⁷^ORCID,Peterson Pärt⁷^ORCID,Lorenzo Lazaro¹²^ORCID,Bizien Lucy¹²^ORCID,Trouillet-Assant Sophie⁸⁹^ORCID,Dobbs Kerry⁴^ORCID,de Jesus Adriana Almeida⁴,Belot Alexandre⁹¹⁰¹¹^ORCID,Kallaste Anne¹²^ORCID,Catherinot Emilie¹³,Tandjaoui-Lambiotte Yacine¹⁴^ORCID,Le Pen Jeremie⁵^ORCID,Kerner Gaspard¹²^ORCID,Bigio Benedetta³^ORCID,Seeleuthner Yoann¹²,Yang Rui³^ORCID,Bolze Alexandre¹⁵^ORCID,Spaan András N.³¹⁶^ORCID,Delmonte Ottavia M.⁴,Abers Michael S.⁴,Aiuti Alessandro¹⁷^ORCID,Casari Giorgio¹⁷,Lampasona Vito¹⁷^ORCID,Piemonti Lorenzo¹⁷^ORCID,Ciceri Fabio¹⁷,Bilguvar Kaya¹⁸^ORCID,Lifton Richard P.¹⁸¹⁹²⁰,Vasse Marc²¹,Smadja David M.²²,Migaud Mélanie¹²^ORCID,Hadjadj Jérome²³^ORCID,Terrier Benjamin²⁴^ORCID,Duffy Darragh²⁵^ORCID,Quintana-Murci Lluis²⁶²⁷^ORCID,van de Beek Diederik²⁸^ORCID,Roussel Lucie²⁹³⁰^ORCID,Vinh Donald C.²⁹³⁰^ORCID,Tangye Stuart G.³¹³²^ORCID,Haerynck Filomeen³³,Dalmau David³⁴^ORCID,Martinez-Picado Javier³⁵³⁶³⁷^ORCID,Brodin Petter³⁸³⁹^ORCID,Nussenzweig Michel C.⁴⁰⁴¹^ORCID,Boisson-Dupuis Stéphanie¹²³^ORCID,Rodríguez-Gallego Carlos⁴²⁴³^ORCID,Vogt Guillaume⁴⁴,Mogensen Trine H.⁴⁵⁴⁶^ORCID,Oler Andrew J.⁴⁷^ORCID,Gu Jingwen⁴⁷,Burbelo Peter D.⁴⁸^ORCID,Cohen Jeffrey I.⁴⁹^ORCID,Biondi Andrea⁵⁰,Bettini Laura Rachele⁵⁰^ORCID,D'Angio Mariella⁵⁰,Bonfanti Paolo⁵¹^ORCID,Rossignol Patrick⁵²,Mayaux Julien⁵³,Rieux-Laucat Frédéric²³^ORCID,Husebye Eystein S.⁵⁴⁵⁵⁵⁶^ORCID,Fusco Francesca⁵⁷,Ursini Matilde Valeria⁵⁷,Imberti Luisa⁵⁸,Sottini Alessandra⁵⁸,Paghera Simone⁵⁸,Quiros-Roldan Eugenia⁵⁹,Rossi Camillo⁶⁰,Castagnoli Riccardo⁶¹^ORCID,Montagna Daniela⁶²⁶³,Licari Amelia⁶¹^ORCID,Marseglia Gian Luigi⁶¹,Duval Xavier⁶⁴⁶⁵⁶⁶⁶⁷⁶⁸,Ghosn Jade⁶⁷⁶⁸,Tsang John S.⁶⁹⁷⁰^ORCID,Goldbach-Mansky Raphaela⁴^ORCID,Kisand Kai⁷^ORCID,Lionakis Michail S.⁴,Puel Anne¹²³^ORCID,Zhang Shen-Ying¹²³,Holland Steven M.⁴^ORCID,Gorochov Guy⁶⁷¹,Jouanguy Emmanuelle¹²³^ORCID,Rice Charles M.⁵,Cobat Aurélie¹²³^ORCID,Notarangelo Luigi D.⁴^ORCID,Abel Laurent¹²³^ORCID,Su Helen C.⁴^ORCID,Casanova Jean-Laurent¹²³⁴¹⁷²^ORCID,Arias Andrés Augusto,Boisson Bertrand,Boucherit Soraya,Bustamante Jacinta,Chbihi Marwa,Chen Jie,Chrabieh Maya,Kochetkov Tatiana,Le Voyer Tom,Liu Dana,Nemirovskaya Yelena,Ogishi Masato,Papandrea Dominick,Patissier Cécile,Rapaport Franck,Roynard Manon,Vladikine Natasha,Woollett Mark,Zhang Peng,Kashyap Anuj,Ding Li,Bosticardo Marita,Wang Qinlu,Ochoa Sebastian,Liu Hui,Chauvin Samuel D.,Stack Michael,Koroleva Galina,Bansal Neha,Dalgard Clifton L.,Snow Andrew L.,Abad Jorge,Aguilera-Albesa Sergio,Akcan Ozge Metin,Darazam Ilad Alavi,Aldave Juan C.,Ramos Miquel Alfonso,Nadji Seyed Alireza,Alkan Gulsum,Allardet-Servent Jerome,Allende Luis M.,Alsina Laia,Alyanakian Marie-Alexandra,Amador-Borrero Blanca,Amoura Zahir,Antolí Arnau,Arslan Sevket,Assant Sophie,Auguet Terese,Azot Axelle,Bajolle Fanny,Baldolli Aurélie,Ballester Maite,Feldman Hagit Baris,Barrou Benoit,Beurton Alexandra,Bilbao Agurtzane,Blanchard-Rohner Geraldine,Blanco Ignacio,Blandinières Adeline,Blazquez-Gamero Daniel,Bloomfield Marketa,Bolivar-Prados Mireia,Borie Raphael,Bousfiha Ahmed A.,Bouvattier Claire,Boyarchuk Oksana,Bueno Maria Rita P.,Bustamante Jacinta,Cáceres Agra Juan José,Calimli Semra,Capra Ruggero,Carrabba Maria,Casasnovas Carlos,Caseris Marion,Castelle Martin,Castelli Francesco,de Vera Martín Castillo,Castro Mateus V.,Catherinot Emilie,Chalumeau Martin,Charbit Bruno,Cheng Matthew P.,Clavé Père,Clotet Bonaventura,Codina Anna,Colkesen Fatih,Colkesen Fatma,Colobran Roger,Comarmond Cloé,Corsico Angelo G.,Dalmau David,Darley David Ross,Dauby Nicolas,Dauger Stéphane,de Pontual Loic,Dehban Amin,Delplancq Geoffroy,Demoule Alexandre,Di Sabatino Antonio,Diehl Jean-Luc,Dobbelaere Stephanie,Durand Sophie,Eldars Waleed,Elgamal Mohamed,Elnagdy Marwa H.,Emiroglu Melike,Erdeniz Emine Hafize,Aytekin Selma Erol,Euvrard Romain,Evcen Recep,Fabio Giovanna,Faivre Laurence,Falck Antonin,Fartoukh Muriel,Faure Morgane,Arquero Miguel Fernandez,Flores Carlos,Francois Bruno,Fumadó Victoria,Fusco Francesca,Solis Blanca Garcia,Gaussem Pascale,Gil-Herrera Juana,Gilardin Laurent,Alarcon Monica Girona,Girona-Alarcón Mónica,Goffard Jean-Christophe,Gok Funda,González-Montelongo Rafaela,Guerder Antoine,Gul Yahya,Guner Sukru Nail,Gut Marta,Hadjadj Jérôme,Haerynck Filomeen,Halwani Rabih,Hammarström Lennart,Hatipoglu Nevin,Hernandez-Brito Elisa,Holanda-Peña María Soledad,Horcajada Juan Pablo,Hraiech Sami,Humbert Linda,Iglesias Alejandro D.,Íñigo-Campos Antonio,Jamme Matthieu,Arranz María Jesús,Jordan Iolanda,Kanat Fikret,Kapakli Hasan,Kara Iskender,Karbuz Adem,Yasar Kadriye Kart,Keles Sevgi,Demirkol Yasemin Kendir,Klocperk Adam,Król Zbigniew J.,Kuentz Paul,Kwan Yat Wah M.,Lagier Jean-Christophe,Lau Yu-Lung,Le Bourgeois Fleur,Leo Yee-Sin,Lopez Rafael Leon,Leung Daniel,Levin Michael,Levy Michael,Lévy Romain,Li Zhi,Linglart Agnes,Lorenzo-Salazar José M.,Louapre Céline,Lubetzki Catherine,Luyt Charles-Edouard,Lye David C.,Mansouri Davood,Marjani Majid,Pereira Jesus Marquez,Martin Andrea,Pueyo David Martínez,Martinez-Picado Javier,Marzana Iciar,Mathian Alexis,Matos Larissa R. B.,Matthews Gail V.,Mayaux Julien,Mège Jean-Louis,Melki Isabelle,Meritet Jean-François,Metin Ozge,Meyts Isabelle,Mezidi Mehdi,Migeotte Isabelle,Millereux Maude,Mirault Tristan,Mircher Clotilde,Mirsaeidi Mehdi,Melián Abián Montesdeoca,Martinez Antonio Morales,Morange Pierre,Mordacq Clémence,Morelle Guillaume,Mouly Stéphane,Muñoz-Barrera Adrián,Nafati Cyril,Neves João Farela,Ng Lisa F. P.,Medina Yeray Novoa,Cuadros Esmeralda Nuñez,Ocejo-Vinyals J. Gonzalo,Orbak Zerrin,Oualha Mehdi,Özçelik Tayfun,Hammarström Qiang Pan,Parizot Christophe,Pascreau Tiffany,Paz-Artal Estela,de Diego Rebeca Pérez,Philippe Aurélien,Philippot Quentin,Planas-Serra Laura,Ploin Dominique,Poissy Julien,Poncelet Géraldine,Pouletty Marie,Quentric Paul,Raoult Didier,Rebillat Anne-Sophie,Reisli Ismail,Ricart Pilar,Richard Jean-Christophe,Rivet Nadia,Rivière Jacques G.,Blanch Gemma Rocamora,Rodrigo Carlos,Rodriguez-Gallego Carlos,Rodríguez-Palmero Agustí,Romero Carolina Soledad,Rothenbuhler Anya,Rozenberg Flore,Ruiz del Prado Maria Yolanda,Riera Joan Sabater,Sanchez Oliver,Sánchez-Ramón Silvia,Schluter Agatha,Schmidt Matthieu,Schweitzer Cyril E.,Scolari Francesco,Sediva Anna,Seijo Luis M.,Sene Damien,Senoglu Sevtap,Seppänen Mikko R. J.,Ilovich Alex Serra,Shahrooei Mohammad,Smadja David,Sobh Ali,Moreno Xavier Solanich,Solé-Violán Jordi,Soler Catherine,Soler-Palacín Pere,Stepanovskiy Yuri,Stoclin Annabelle,Taccone Fabio,Tandjaoui-Lambiotte Yacine,Taupin Jean-Luc,Tavernier Simon J.,Terrier Benjamin,Thumerelle Caroline,Tomasoni Gabriele,Toubiana Julie,Alvarez Josep Trenado,Trouillet-Assant Sophie,Troya Jesús,Tucci Alessandra,Ursini Matilde Valeria,Uzunhan Yurdagul,Vabres Pierre,Valencia-Ramos Juan,Van Den Rym Ana Maria,Vandernoot Isabelle,Vatansev Hulya,Vélez-Santamaria Valentina,Viel Sébastien,Vilain Cédric,Vilaire Marie E.,Vincent Audrey,Voiriot Guillaume,Vuotto Fanny,Yosunkaya Alper,Young Barnaby E.,Yucel Fatih,Zannad Faiez,Zatz Mayana,Belot Alexandre,Foti Giuseppe,Bellani Giacomo,Citerio Giuseppe,Contro Ernesto,Pesci Alberto,Valsecchi Maria Grazia,Cazzaniga Marina,Bole-Feysot Christine,Lyonnet Stanislas,Masson Cécile,Nitschke Patrick,Pouliet Aurore,Schmitt Yoann,Tores Frederic,Zarhrate Mohammed,Abel Laurent,Andrejak Claire,Angoulvant François,Bachelet Delphine,Basmaci Romain,Behillil Sylvie,Beluze Marine,Benkerrou Dehbia,Bhavsar Krishna,Bompart François,Bouadma Lila,Bouscambert Maude,Caralp Mireille,Cervantes-Gonzalez Minerva,Chair Anissa,Coelho Alexandra,Couffignal Camille,Couffin-Cadiergues Sandrine,D’ortenzio Eric,Da Silveira Charlene,Debray Marie-Pierre,Deplanque Dominique,Descamps Diane,Desvallées Mathilde,Diallo Alpha,Diouf Alphonsine,Dorival Céline,Dubos François,Duval Xavier,Eloy Philippine,Enouf Vincent V. E.,Esperou Hélène,Esposito-Farese Marina,Etienne Manuel,Ettalhaoui Nadia,Gault Nathalie,Gaymard Alexandre,Ghosn Jade,Gigante Tristan,Gorenne Isabelle,Guedj Jérémie,Hoctin Alexandre,Hoffmann Isabelle,Jaafoura Salma,Kafif Ouifiya,Kaguelidou Florentia,Kali Sabina,Khalil Antoine,Khan Coralie,Laouénan Cédric,Laribi Samira,Le Minh,Le Hingrat Quentin,Le Mestre Soizic,Le Nagard Hervé,Lescure François-Xavier,Lévy Yves,Levy-Marchal Claire,Lina Bruno,Lingas Guillaume,Lucet Jean Christophe,Malvy Denis,Mambert Marina,Mentré France,Mercier Noémie,Meziane Amina,Mouquet Hugo,Mullaert Jimmy,Neant Nadège,Noret Marion,Pages Justine,Papadopoulos Aurélie,Paul Christelle,Peiffer-Smadja Nathan,Petrov-Sanchez Ventzislava,Peytavin Gilles,Picone Olivier,Puéchal Oriane,Rosa-Calatrava Manuel,Rossignol Bénédicte,Rossignol Patrick,Roy Carine,Schneider Marion,Semaille Caroline,Mohammed Nassima Si,Tagherset Lysa,Tardivon Coralie,Tellier Marie-Capucine,Téoulé François,Terrier Olivier,Timsit Jean-François,Treoux Théo,Tual Christelle,Tubiana Sarah,van der Werf Sylvie,Vanel Noémie,Veislinger Aurélie,Visseaux Benoit,Wiedemann Aurélie,Yazdanpanah Yazdan,Abel Laurent,Alcover Andres,Aschard Hugues,Astrom Kalla,Bousso Philippe,Bruhns Pierre,Cumano Ana,Demangel Caroline,Deriano Ludovic,Di Santo James,Dromer Françoise,Eberl Gérard,Enninga Jost,Fellay Jacques,Gomperts-Boneca Ivo,Hasan Milena,Hercberg Serge,Lantz Olivier,Mouquet Hugo,Patin Etienne,Pellegrini Sandra,Pol Stanislas,Rausell Antonio,Rogge Lars,Sakuntabhai Anavaj,Schwartz Olivier,Schwikowski Benno,Shorte Spencer,Tangy Frédéric,Toubert Antoine,Touvier Mathilde,Ungeheuer Marie-Noëlle,Albert Matthew L.,Duffy Darragh,Quintana-Murci Lluis,Alavoine Loubna,Amat Karine K. A.,Behillil Sylvie,Bielicki Julia,Bruijning Patricia,Burdet Charles,Caumes Eric,Charpentier Charlotte,Coignard Bruno,Costa Yolande,Couffin-Cadiergues Sandrine,Damond Florence,Dechanet Aline,Delmas Christelle,Descamps Diane,Duval Xavier,Ecobichon Jean-Luc,Enouf Vincent,Espérou Hélène,Frezouls Wahiba,Houhou Nadhira,Ilic-Habensus Emila,Kafif Ouifiya,Kikoine John,Le Hingrat Quentin,Lebeaux David,Leclercq Anne,Lehacaut Jonathan,Letrou Sophie,Lina Bruno,Lucet Jean-Christophe,Malvy Denis,Manchon Pauline,Mandic Milica,Meghadecha Mohamed,Motiejunaite Justina,Nouroudine Mariama,Piquard Valentine,Postolache Andreea,Quintin Caroline,Rexach Jade,Roufai Layidé,Terzian Zaven,Thy Michael,Tubiana Sarah,van der Werf Sylvie,Vignali Valérie,Visseaux Benoit,Yazdanpanah Yazdan,van Agtmael Michiel,Algera Anna Geke,van Baarle Frank,Bax Diane,Beudel Martijn,Bogaard Harm Jan,Bomers Marije,Bos Lieuwe,Botta Michela,de Brabander Justin,Bree Godelieve,Brouwer Matthijs C.,de Bruin Sanne,Bugiani Marianna,Bulle Esther,Chouchane Osoul,Cloherty Alex,Elbers Paul,Fleuren Lucas,Geerlings Suzanne,Geerts Bart,Geijtenbeek Theo,Girbes Armand,Goorhuis Bram,Grobusch Martin P.,Hafkamp Florianne,Hagens Laura,Hamann Jorg,Harris Vanessa,Hemke Robert,Hermans Sabine M.,Heunks Leo,Hollmann Markus W.,Horn Janneke,Hovius Joppe W.,de Jong Menno D.,Koning Rutger,van Mourik Niels,Nellen Jeaninne,Paulus Frederique,Peters Edgar,van der Poll Tom,Preckel Benedikt,Prins Jan M.,Raasveld Jorinde,Reijnders Tom,Schinkel Michiel,Schultz Marcus J.,Schuurman Alex,Sigaloff Kim,Smit Marry,Stijnis Cornelis S.,Stilma Willemke,Teunissen Charlotte,Thoral Patrick,Tsonas Anissa,van der Valk Marc,Veelo Denise,Vlaar Alexander P. J.,de Vries Heder,van Vugt Michèle,Wiersinga W. Joost,Wouters Dorien,Zwinderman A. H. (Koos),van de Beek Diederik,Abel Laurent,Aiuti Alessandro,Al Muhsen Saleh,Al-Mulla Fahd,Anderson Mark S.,Arias Andrés Augusto,Feldman Hagit Baris,Bogunovic Dusan,Bolze Alexandre,Bondarenko Anastasiia,Bousfiha Ahmed A.,Brodin Petter,Bryceson Yenan,Bustamante Carlos D.,Butte Manish,Casari Giorgio,Chakravorty Samya,Christodoulou John,Cirulli Elizabeth,Condino-Neto Antonio,Cooper Megan A.,Dalgard Clifton L.,DeRisi Joseph L.,Desai Murkesh,Drolet Beth A.,Espinosa Sara,Fellay Jacques,Flores Carlos,Franco Jose Luis,Gregersen Peter K.,Haerynck Filomeen,Hagin David,Halwani Rabih,Heath Jim,Henrickson Sarah E.,Hsieh Elena,Imai Kohsuke,Itan Yuval,Karamitros Timokratis,Kisand Kai,Ku Cheng-Lung,Lau Yu-Lung,Ling Yun,Lucas Carrie L.,Maniatis Tom,Mansouri Davoud,Marodi Laszlo,Meyts Isabelle,Milner Joshua D.,Mironska Kristina,Mogensen Trine,Morio Tomohiro,Ng Lisa F. P.,Notarangelo Luigi D.,Novelli Giuseppe,Novelli Antonio,O'Farrelly Cliona,Okada Satoshi,Ozcelik Tayfun,de Diego Rebeca Perez,Planas Anna M.,Prando Carolina,Pujol Aurora,Quintana-Murci Lluis,Renia Laurent,Renieri Alessandra,Rodríguez-Gallego Carlos,Sancho-Shimizu Vanessa,Sankaran Vijay,Barrett Kelly Schiabor,Shahrooei Mohammed,Snow Andrew,Soler-Palacín Pere,Spaan András N.,Tangye Stuart,Turvey Stuart,Uddin Furkan,Uddin Mohammed J.,van de Beek Diederik,Vazquez Sara E.,Vinh Donald C.,von Bernuth Horst,Washington Nicole,Zawadzki Pawel,Su Helen C.,Casanova Jean-Laurent, , , , , , , , , ,

Affiliation:

1. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.

2. University of Paris, Imagine Institute, Paris, France.

3. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

4. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

5. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.

6. Sorbonne Université, INSERM, Centre d’Immunologie et des Maladies Infectieuses, (CIMI-Paris), Paris, France.

7. Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

8. Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.

9. International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France.

10. National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children (RAISE), Lyon, France.

11. Lyon Immunopathology Federation (LIFE), Hospices Civils de Lyon, Lyon, France.

12. Internal Medicine Clinic, Tartu University Hospital, Tartu, Estonia.

13. Pneumology Department, Foch Hospital, Suresne, France.

14. Avicenne Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Bobigny, INSERM U1272 Hypoxia and Lung, Bobigny, France.

15. Helix, San Mateo, CA, USA.

16. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands.

17. IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy.

18. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.

19. Yale Center for Genome Analysis, Yale University School of Medicine, New Haven, CT, USA.

20. Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY, USA.

21. Service de Biologie Clinique and UMR-S 1176, Hôpital Foch, Suresnes, France.

22. INSERM UMR-S 1140, Biosurgical Research Laboratory (Carpentier Foundation), Paris University and European Georges Pompidou Hospital, Paris, France.

23. Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.

24. Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), University of Paris, Paris, France.

25. Translational Immunology Laboratory, Institut Pasteur, Paris, France.

26. Human Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, 75015, Paris, France.

27. Human Genomics and Evolution, Collège de France, Paris, France.

28. Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands.

29. Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.

30. Infectious Disease Susceptibility Program, Research Institute, McGill University Health Centre, Montréal, Québec, Canada.

31. Garvan Institute of Medical Research, Darlinghurst 2010, NSW, Sydney, Australia.

32. St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Sydney, Darlinghurst 2010, NSW, Australia.

33. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Laboratory, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium.

34. Infectious Diseases and HIV Service, Hospital Universitari Mutua Terrassa, Universitat de Barcelona, Fundació Docència i Recerca Mutua Terrassa, Terrassa, Barcelona, Catalonia, Spain.

35. IrsiCaixa AIDS Research Institute and Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain.

36. Infectious Diseases and Immunity, Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.

37. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.

38. Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Karolinska, Sweden.

39. Department of Pediatric Rheumatology, Karolinska University Hospital, Karolinska, Sweden.

40. Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

41. Howard Hughes Medical Institute, New York, NY, USA.

42. Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain.

43. Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.

44. Neglected Human Genetics Laboratory, INSERM, University of Paris, Paris, France.

45. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.

46. Department of Biomedicine, Aarhus University, Aarhus, Denmark.

47. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.

48. Division of Intramural Research, National Institute of Dental Craniofacial Research (NIDCR), NIH, Bethesda, MD, USA.

49. Laboratory of Infectious Diseases, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.

50. Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy.

51. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy.

52. University of Lorraine, Plurithematic Clinical Investigation Centre INSERM CIC-P 1433, INSERM U1116, CHRU Nancy Hopitaux de Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.

53. Intensive Care Unit, Pitié-Salpétrière Hospital, Paris University, AP-HP, Paris, France.

54. Department of Clinical Science and K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway.

55. Department of Medicine, Haukeland University Hospital, Bergen, Norway.

56. Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.

57. Human Molecular Genetics Laboratory, Institute of Genetics and Biophysics, “A. Buzzati-Traverso” Consiglio Nazionale delle Ricerche, Naples, Italy.

58. Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.

59. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy.

60. Direzione Sanitaria, ASST Spedali Civili di Brescia, Brescia, Italy.

61. Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

62. Laboratory of Immunology and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

63. Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

64. INSERM CIC 1425, Paris, France.

65. AP-HP, University Hospital of Bichat, Paris, France.

66. University Paris Diderot, Paris 7, UFR de Médecine-Bichat, Paris, France.

67. Infection, Antimicrobials, Modelling, Evolution (IAME), INSERM, UMRS1137, University of Paris, Paris, France.

68. AP-HP, Bichat Claude Bernard Hospital, Infectious and Tropical Diseases Department, Paris, France.

69. Center for Human Immunology, NIH, Bethesda, MD, USA.

70. Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.

71. Département d’Immunologie, AP-HP, Hôpital Pitié-Salpétrière, Paris, France.

72. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.

Abstract

The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induced inflammation. Two studies now examine the likelihood that genetics affects the risk of severe coronavirus disease 2019 (COVID-19) through components of this system (see the Perspective by Beck and Aksentijevich). Q. Zhang et al. used a candidate gene approach and identified patients with severe COVID-19 who have mutations in genes involved in the regulation of type I and III IFN immunity. They found enrichment of these genes in patients and conclude that genetics may determine the clinical course of the infection. Bastard et al. identified individuals with high titers of neutralizing autoantibodies against type I IFN-α2 and IFN-ω in about 10% of patients with severe COVID-19 pneumonia. These autoantibodies were not found either in infected people who were asymptomatic or had milder phenotype or in healthy individuals. Together, these studies identify a means by which individuals at highest risk of life-threatening COVID-19 can be identified. Science , this issue p. eabd4570 , p. eabd4585 ; see also p. 404

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference45 articles.

1. The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?

2. Autoantibodies to Interferon‐γ in a Patient with Selective Susceptibility to Mycobacterial Infection and Organ‐Specific Autoimmunity

3. Naturally occurring anti–IFN-γ autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans

4. Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-γ

5. Recurrent Staphylococcal Cellulitis and Subcutaneous Abscesses in a Child with Autoantibodies against IL-6

Cited by 1942 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Autoimmune response after SARS-CoV-2 infection and SARS-CoV-2 vaccines;Autoimmunity Reviews;2024-03

2. Life-threatening infections in human newborns: Reconciling age-specific vulnerability and interindividual variability;Cellular Immunology;2024-03

3. Inborn errors of immunity illuminate mechanisms of human immunology and pave the road to precision medicine;Immunological Reviews;2024-02-02

4. Pathogenesis of Pulmonary Long COVID-19;Modern Pathology;2024-02

5. Human coronavirus OC43-elicited CD4+ T cells protect against SARS-CoV-2 in HLA transgenic mice;Nature Communications;2024-01-26