Autoantibodies against type I IFNs in patients with life-threatening COVID-19-Reference-Cited by-同舟云学术

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Published:2020-10-23 Issue:6515 Volume:370 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bastard Paul¹²³^ORCID,Rosen Lindsey B.⁴^ORCID,Zhang Qian³^ORCID,Michailidis Eleftherios⁵^ORCID,Hoffmann Hans-Heinrich⁵^ORCID,Zhang Yu⁴,Dorgham Karim⁶^ORCID,Philippot Quentin¹²,Rosain Jérémie¹²,Béziat Vivien¹²³^ORCID,Manry Jérémy¹²^ORCID,Shaw Elana⁴^ORCID,Haljasmägi Liis⁷^ORCID,Peterson Pärt⁷^ORCID,Lorenzo Lazaro¹²^ORCID,Bizien Lucy¹²^ORCID,Trouillet-Assant Sophie⁸⁹^ORCID,Dobbs Kerry⁴^ORCID,de Jesus Adriana Almeida⁴,Belot Alexandre⁹¹⁰¹¹^ORCID,Kallaste Anne¹²^ORCID,Catherinot Emilie¹³,Tandjaoui-Lambiotte Yacine¹⁴^ORCID,Le Pen Jeremie⁵^ORCID,Kerner Gaspard¹²^ORCID,Bigio Benedetta³^ORCID,Seeleuthner Yoann¹²,Yang Rui³^ORCID,Bolze Alexandre¹⁵^ORCID,Spaan András N.³¹⁶^ORCID,Delmonte Ottavia M.⁴,Abers Michael S.⁴,Aiuti Alessandro¹⁷^ORCID,Casari Giorgio¹⁷,Lampasona Vito¹⁷^ORCID,Piemonti Lorenzo¹⁷^ORCID,Ciceri Fabio¹⁷,Bilguvar Kaya¹⁸^ORCID,Lifton Richard P.¹⁸¹⁹²⁰,Vasse Marc²¹,Smadja David M.²²,Migaud Mélanie¹²^ORCID,Hadjadj Jérome²³^ORCID,Terrier Benjamin²⁴^ORCID,Duffy Darragh²⁵^ORCID,Quintana-Murci Lluis²⁶²⁷^ORCID,van de Beek Diederik²⁸^ORCID,Roussel Lucie²⁹³⁰^ORCID,Vinh Donald C.²⁹³⁰^ORCID,Tangye Stuart G.³¹³²^ORCID,Haerynck Filomeen³³,Dalmau David³⁴^ORCID,Martinez-Picado Javier³⁵³⁶³⁷^ORCID,Brodin Petter³⁸³⁹^ORCID,Nussenzweig Michel C.⁴⁰⁴¹^ORCID,Boisson-Dupuis Stéphanie¹²³^ORCID,Rodríguez-Gallego Carlos⁴²⁴³^ORCID,Vogt Guillaume⁴⁴,Mogensen Trine H.⁴⁵⁴⁶^ORCID,Oler Andrew J.⁴⁷^ORCID,Gu Jingwen⁴⁷,Burbelo Peter D.⁴⁸^ORCID,Cohen Jeffrey I.⁴⁹^ORCID,Biondi Andrea⁵⁰,Bettini Laura Rachele⁵⁰^ORCID,D'Angio Mariella⁵⁰,Bonfanti Paolo⁵¹^ORCID,Rossignol Patrick⁵²,Mayaux Julien⁵³,Rieux-Laucat Frédéric²³^ORCID,Husebye Eystein S.⁵⁴⁵⁵⁵⁶^ORCID,Fusco Francesca⁵⁷,Ursini Matilde Valeria⁵⁷,Imberti Luisa⁵⁸,Sottini Alessandra⁵⁸,Paghera Simone⁵⁸,Quiros-Roldan Eugenia⁵⁹,Rossi Camillo⁶⁰,Castagnoli Riccardo⁶¹^ORCID,Montagna Daniela⁶²⁶³,Licari Amelia⁶¹^ORCID,Marseglia Gian Luigi⁶¹,Duval Xavier⁶⁴⁶⁵⁶⁶⁶⁷⁶⁸,Ghosn Jade⁶⁷⁶⁸,Tsang John S.⁶⁹⁷⁰^ORCID,Goldbach-Mansky Raphaela⁴^ORCID,Kisand Kai⁷^ORCID,Lionakis Michail S.⁴,Puel Anne¹²³^ORCID,Zhang Shen-Ying¹²³,Holland Steven M.⁴^ORCID,Gorochov Guy⁶⁷¹,Jouanguy Emmanuelle¹²³^ORCID,Rice Charles M.⁵,Cobat Aurélie¹²³^ORCID,Notarangelo Luigi D.⁴^ORCID,Abel Laurent¹²³^ORCID,Su Helen C.⁴^ORCID,Casanova Jean-Laurent¹²³⁴¹⁷²^ORCID,Arias Andrés Augusto,Boisson Bertrand,Boucherit Soraya,Bustamante Jacinta,Chbihi Marwa,Chen Jie,Chrabieh Maya,Kochetkov Tatiana,Le Voyer Tom,Liu Dana,Nemirovskaya Yelena,Ogishi Masato,Papandrea Dominick,Patissier Cécile,Rapaport Franck,Roynard Manon,Vladikine Natasha,Woollett Mark,Zhang Peng,Kashyap Anuj,Ding Li,Bosticardo Marita,Wang Qinlu,Ochoa Sebastian,Liu Hui,Chauvin Samuel D.,Stack Michael,Koroleva Galina,Bansal Neha,Dalgard Clifton L.,Snow Andrew L.,Abad Jorge,Aguilera-Albesa Sergio,Akcan Ozge Metin,Darazam Ilad Alavi,Aldave Juan C.,Ramos Miquel Alfonso,Nadji Seyed Alireza,Alkan Gulsum,Allardet-Servent Jerome,Allende Luis M.,Alsina Laia,Alyanakian Marie-Alexandra,Amador-Borrero Blanca,Amoura Zahir,Antolí Arnau,Arslan Sevket,Assant Sophie,Auguet Terese,Azot Axelle,Bajolle Fanny,Baldolli Aurélie,Ballester Maite,Feldman Hagit Baris,Barrou Benoit,Beurton Alexandra,Bilbao Agurtzane,Blanchard-Rohner Geraldine,Blanco Ignacio,Blandinières Adeline,Blazquez-Gamero Daniel,Bloomfield Marketa,Bolivar-Prados Mireia,Borie Raphael,Bousfiha Ahmed A.,Bouvattier Claire,Boyarchuk Oksana,Bueno Maria Rita P.,Bustamante Jacinta,Cáceres Agra Juan José,Calimli Semra,Capra Ruggero,Carrabba Maria,Casasnovas Carlos,Caseris Marion,Castelle Martin,Castelli Francesco,de Vera Martín Castillo,Castro Mateus V.,Catherinot Emilie,Chalumeau Martin,Charbit Bruno,Cheng Matthew P.,Clavé Père,Clotet Bonaventura,Codina Anna,Colkesen Fatih,Colkesen Fatma,Colobran Roger,Comarmond Cloé,Corsico Angelo G.,Dalmau David,Darley David Ross,Dauby Nicolas,Dauger Stéphane,de Pontual Loic,Dehban Amin,Delplancq Geoffroy,Demoule Alexandre,Di Sabatino Antonio,Diehl Jean-Luc,Dobbelaere Stephanie,Durand Sophie,Eldars Waleed,Elgamal Mohamed,Elnagdy Marwa H.,Emiroglu Melike,Erdeniz Emine Hafize,Aytekin Selma Erol,Euvrard Romain,Evcen Recep,Fabio Giovanna,Faivre Laurence,Falck Antonin,Fartoukh Muriel,Faure Morgane,Arquero Miguel Fernandez,Flores Carlos,Francois Bruno,Fumadó Victoria,Fusco Francesca,Solis Blanca Garcia,Gaussem Pascale,Gil-Herrera Juana,Gilardin Laurent,Alarcon Monica Girona,Girona-Alarcón Mónica,Goffard Jean-Christophe,Gok Funda,González-Montelongo Rafaela,Guerder Antoine,Gul Yahya,Guner Sukru Nail,Gut Marta,Hadjadj Jérôme,Haerynck Filomeen,Halwani Rabih,Hammarström Lennart,Hatipoglu Nevin,Hernandez-Brito Elisa,Holanda-Peña María Soledad,Horcajada Juan Pablo,Hraiech Sami,Humbert Linda,Iglesias Alejandro D.,Íñigo-Campos Antonio,Jamme Matthieu,Arranz María Jesús,Jordan Iolanda,Kanat Fikret,Kapakli Hasan,Kara Iskender,Karbuz Adem,Yasar Kadriye Kart,Keles Sevgi,Demirkol Yasemin Kendir,Klocperk Adam,Król Zbigniew J.,Kuentz Paul,Kwan Yat Wah M.,Lagier Jean-Christophe,Lau Yu-Lung,Le Bourgeois Fleur,Leo 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J.,de Vries Heder,van Vugt Michèle,Wiersinga W. Joost,Wouters Dorien,Zwinderman A. H. (Koos),van de Beek Diederik,Abel Laurent,Aiuti Alessandro,Al Muhsen Saleh,Al-Mulla Fahd,Anderson Mark S.,Arias Andrés Augusto,Feldman Hagit Baris,Bogunovic Dusan,Bolze Alexandre,Bondarenko Anastasiia,Bousfiha Ahmed A.,Brodin Petter,Bryceson Yenan,Bustamante Carlos D.,Butte Manish,Casari Giorgio,Chakravorty Samya,Christodoulou John,Cirulli Elizabeth,Condino-Neto Antonio,Cooper Megan A.,Dalgard Clifton L.,DeRisi Joseph L.,Desai Murkesh,Drolet Beth A.,Espinosa Sara,Fellay Jacques,Flores Carlos,Franco Jose Luis,Gregersen Peter K.,Haerynck Filomeen,Hagin David,Halwani Rabih,Heath Jim,Henrickson Sarah E.,Hsieh Elena,Imai Kohsuke,Itan Yuval,Karamitros Timokratis,Kisand Kai,Ku Cheng-Lung,Lau Yu-Lung,Ling Yun,Lucas Carrie L.,Maniatis Tom,Mansouri Davoud,Marodi Laszlo,Meyts Isabelle,Milner Joshua D.,Mironska Kristina,Mogensen Trine,Morio Tomohiro,Ng Lisa F. P.,Notarangelo Luigi D.,Novelli Giuseppe,Novelli Antonio,O'Farrelly Cliona,Okada Satoshi,Ozcelik Tayfun,de Diego Rebeca Perez,Planas Anna M.,Prando Carolina,Pujol Aurora,Quintana-Murci Lluis,Renia Laurent,Renieri Alessandra,Rodríguez-Gallego Carlos,Sancho-Shimizu Vanessa,Sankaran Vijay,Barrett Kelly Schiabor,Shahrooei Mohammed,Snow Andrew,Soler-Palacín Pere,Spaan András N.,Tangye Stuart,Turvey Stuart,Uddin Furkan,Uddin Mohammed J.,van de Beek Diederik,Vazquez Sara E.,Vinh Donald C.,von Bernuth Horst,Washington Nicole,Zawadzki Pawel,Su Helen C.,Casanova Jean-Laurent, , , , , , , , , ,

Affiliation:

1. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.

2. University of Paris, Imagine Institute, Paris, France.

3. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

4. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

5. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.

6. Sorbonne Université, INSERM, Centre d’Immunologie et des Maladies Infectieuses, (CIMI-Paris), Paris, France.

7. Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

8. Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.

9. International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France.

10. National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children (RAISE), Lyon, France.

11. Lyon Immunopathology Federation (LIFE), Hospices Civils de Lyon, Lyon, France.

12. Internal Medicine Clinic, Tartu University Hospital, Tartu, Estonia.

13. Pneumology Department, Foch Hospital, Suresne, France.

14. Avicenne Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Bobigny, INSERM U1272 Hypoxia and Lung, Bobigny, France.

15. Helix, San Mateo, CA, USA.

16. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands.

17. IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy.

18. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.

19. Yale Center for Genome Analysis, Yale University School of Medicine, New Haven, CT, USA.

20. Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY, USA.

21. Service de Biologie Clinique and UMR-S 1176, Hôpital Foch, Suresnes, France.

22. INSERM UMR-S 1140, Biosurgical Research Laboratory (Carpentier Foundation), Paris University and European Georges Pompidou Hospital, Paris, France.

23. Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.

24. Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), University of Paris, Paris, France.

25. Translational Immunology Laboratory, Institut Pasteur, Paris, France.

26. Human Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, 75015, Paris, France.

27. Human Genomics and Evolution, Collège de France, Paris, France.

28. Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands.

29. Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.

30. Infectious Disease Susceptibility Program, Research Institute, McGill University Health Centre, Montréal, Québec, Canada.

31. Garvan Institute of Medical Research, Darlinghurst 2010, NSW, Sydney, Australia.

32. St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Sydney, Darlinghurst 2010, NSW, Australia.

33. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Laboratory, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium.

34. Infectious Diseases and HIV Service, Hospital Universitari Mutua Terrassa, Universitat de Barcelona, Fundació Docència i Recerca Mutua Terrassa, Terrassa, Barcelona, Catalonia, Spain.

35. IrsiCaixa AIDS Research Institute and Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain.

36. Infectious Diseases and Immunity, Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.

37. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.

38. Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Karolinska, Sweden.

39. Department of Pediatric Rheumatology, Karolinska University Hospital, Karolinska, Sweden.

40. Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

41. Howard Hughes Medical Institute, New York, NY, USA.

42. Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain.

43. Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.

44. Neglected Human Genetics Laboratory, INSERM, University of Paris, Paris, France.

45. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.

46. Department of Biomedicine, Aarhus University, Aarhus, Denmark.

47. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.

48. Division of Intramural Research, National Institute of Dental Craniofacial Research (NIDCR), NIH, Bethesda, MD, USA.

49. Laboratory of Infectious Diseases, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.

50. Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy.

51. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy.

52. University of Lorraine, Plurithematic Clinical Investigation Centre INSERM CIC-P 1433, INSERM U1116, CHRU Nancy Hopitaux de Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.

53. Intensive Care Unit, Pitié-Salpétrière Hospital, Paris University, AP-HP, Paris, France.

54. Department of Clinical Science and K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway.

55. Department of Medicine, Haukeland University Hospital, Bergen, Norway.

56. Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.

57. Human Molecular Genetics Laboratory, Institute of Genetics and Biophysics, “A. Buzzati-Traverso” Consiglio Nazionale delle Ricerche, Naples, Italy.

58. Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.

59. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy.

60. Direzione Sanitaria, ASST Spedali Civili di Brescia, Brescia, Italy.

61. Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

62. Laboratory of Immunology and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

63. Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

64. INSERM CIC 1425, Paris, France.

65. AP-HP, University Hospital of Bichat, Paris, France.

66. University Paris Diderot, Paris 7, UFR de Médecine-Bichat, Paris, France.

67. Infection, Antimicrobials, Modelling, Evolution (IAME), INSERM, UMRS1137, University of Paris, Paris, France.

68. AP-HP, Bichat Claude Bernard Hospital, Infectious and Tropical Diseases Department, Paris, France.

69. Center for Human Immunology, NIH, Bethesda, MD, USA.

70. Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.

71. Département d’Immunologie, AP-HP, Hôpital Pitié-Salpétrière, Paris, France.

72. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.

Abstract

The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induced inflammation. Two studies now examine the likelihood that genetics affects the risk of severe coronavirus disease 2019 (COVID-19) through components of this system (see the Perspective by Beck and Aksentijevich). Q. Zhang et al. used a candidate gene approach and identified patients with severe COVID-19 who have mutations in genes involved in the regulation of type I and III IFN immunity. They found enrichment of these genes in patients and conclude that genetics may determine the clinical course of the infection. Bastard et al. identified individuals with high titers of neutralizing autoantibodies against type I IFN-α2 and IFN-ω in about 10% of patients with severe COVID-19 pneumonia. These autoantibodies were not found either in infected people who were asymptomatic or had milder phenotype or in healthy individuals. Together, these studies identify a means by which individuals at highest risk of life-threatening COVID-19 can be identified. Science , this issue p. eabd4570 , p. eabd4585 ; see also p. 404

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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3. Naturally occurring anti–IFN-γ autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans

4. Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-γ

5. Recurrent Staphylococcal Cellulitis and Subcutaneous Abscesses in a Child with Autoantibodies against IL-6

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