Causes of early-onset type 1 diabetes: toward data-driven environmental approaches-Reference-Cited by-同舟云学术

Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

Published:2008-12-15 Issue:13 Volume:205 Page:2953-2957
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Bougnères Pierre¹,Valleron Alain-Jacques²

Affiliation:

1. P.B. is at Department of Pediatric Endocrinology and U561 INSERM, Saint Vincent de Paul Hospital, Paris V René Descartes University, 75014 Paris, France

2. A.-J.V. is at Unité de Santé Publique and U707 INSERM, Saint Antoine Hospital, Paris VI Pierre et Marie Curie University, 75012 Paris, France

Abstract

A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and β cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/205/13/2953/1197315/jem_20082622.pdf

Reference34 articles.

1. Histocompatibility-Linked Immune Response Genes

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3. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.

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