Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

Author:

Bougnères Pierre1,Valleron Alain-Jacques2

Affiliation:

1. P.B. is at Department of Pediatric Endocrinology and U561 INSERM, Saint Vincent de Paul Hospital, Paris V René Descartes University, 75014 Paris, France

2. A.-J.V. is at Unité de Santé Publique and U707 INSERM, Saint Antoine Hospital, Paris VI Pierre et Marie Curie University, 75012 Paris, France

Abstract

A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and β cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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