Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

Author:

Mackay Fabienne1,Woodcock Stephen A.1,Lawton Pornsri1,Ambrose Christine1,Baetscher Manfred2,Schneider Pascal3,Tschopp Jurg3,Browning Jeffrey L.1

Affiliation:

1. Department of Immunology, Inflammation and Cell Biology, Biogen, Cambridge, Massachusetts 02142

2. Oregon Health Sciences University, Portland, Oregon 97201-9847

3. Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland

Abstract

The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated production of tumor necrosis factor (TNF) family members appears to be important in many cases. BAFF, a new member of the TNF family, binds to B cells and costimulates their growth in vitro. Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti–DNA autoantibodies, and immunoglobulin deposition in the kidneys. This phenotype is reminiscent of certain human autoimmune disorders and suggests that dysregulation of BAFF expression may be a critical element in the chain of events leading to autoimmunity.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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