Bilateral Paget Disease of the Nipple Associated With Lobular Carcinoma In Situ

Author:

Sahoo Sunati1,Green Ileana1,Rosen Paul P.1

Affiliation:

1. From the Department of Pathology, New York Presbyterian Hospital–Weill Cornell Medical Center, New York, NY (Drs Sahoo and Rosen); and the Department of Pathology, Lenox Hill Hospital, New York, NY (Dr Green).

Abstract

Abstract We report synchronous bilateral Paget disease derived from lobular carcinoma in situ in a 53-year-old woman who underwent bilateral mastectomy. The epidermis of both nipples contained small cells with a moderate amount of pale-staining cytoplasm. The nuclei had fine chromatin and identifiable nucleoli. The cells were strongly immunoreactive with cytokeratin 7 and displayed nuclear estrogen receptor reactivity. The underlying mammary gland showed involvement by lobular carcinoma in situ with pagetoid spread into lactiferous ducts, which was confirmed by lack of immunoreactivity for E-cadherin.

Publisher

Archives of Pathology and Laboratory Medicine

Subject

Medical Laboratory Technology,General Medicine,Pathology and Forensic Medicine

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Nipple Lesions of the Breast;Advances in Anatomic Pathology;2023-09-26

2. Paget Disease of the Breast;The Breast;2018

3. Breast;Rosai and Ackerman's Surgical Pathology;2011

4. Synchronous unilateral triple breast cancers composed of invasive ductal carcinoma, invasive lobular carcinoma, and Paget’s disease;Breast Cancer;2010-12-08

5. Paget’s Disease of the Breast;Breast Surgical Techniques and Interdisciplinary Management;2010

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