Author:
Kamyshna I.I., ,Pavlovych L.B.,Kamyshnyi A.M., ,
Abstract
Our work aimed to study the influence of cholecalciferol on neurogenesis, neurotrophins and their receptors pathway-focused genes expression in patients with autoimmune thyroiditis and hypothyroidism. The pathway-specific PCR array (Neurotrophins and Receptors RT2 Profiler PCR Array, “QIAGEN”, Germany) was used to identify and validate the neurogenesis regulatory genes expression in patients with thyroid pathology and control group. The results showed that in patients with autoimmune thyroiditis-caused primary hypothyroidism, the expression of BDNF, FAS, FGF2, HSPB1, IL10, NGF, NGFR, NRG1, NTF3, NTF4, TGFB1, and TP53 were increased after treatment with cholecalciferol and L-thyroxine. The mRNA levels of BAX, GDNF, CD40, FOS, GDNF, GFRA1, IL1B, and STAT3 were significantly decreased in patients with autoimmune thyroiditis-caused primary hypothyroidism after treatment with cholecalciferol and Lthyroxine compared to the patients who received only L-thyroxine. Therefore, the addition of vitamin D to standard therapy alters the transcriptional profile of blood cells in patients with primary hypothyroidism.
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)
Reference48 articles.
1. AARON, Jessi y Rena TORRES CACOULLOS (2005): «Quantitative measures of subjectification: A variationist study of Spanish salir(se)», Cognitive Linguistics, 16(4), pp. 607-633.
2. ALCINA FRANCH, Juan y José Manuel BLECUA (1975): Gramática española, Barcelona, Ariel.
3. ARCE-ARENALES, Manuel (1989): Semantic structure and syntactic function: The case of Spanish SE, Tesis doctoral, University of Colorado.
4. ARMSTRONG, Grant (2013): «Agentive reflexive clitics and transitive se constructions in Spanish», Borealis, 2(2), pp. 81-128.
5. «SE-marked directed motion constructions: anticausatives and figure reflexives», en Jonathan Macdonald (ed;ARMSTRONG;) Contemporary trends in hispanic and lusophone linguistics,2018
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献