THE EFFECT OF COENZYME Q10 ADMINISTRATION ON THE EXPRESSION OF Gdnf, Plzf, Sox3, Thy1 GENES IN RATS WITH HYPOTHYROIDISM

Abstract

Objective: Hypothyroidism is a problem of deficient production of thyroid hormones. These hormones regulate metabolism. Therefore, the current health status of the person is adversely affected due to thyroid hormone deficiency. Coenzyme Q10 (CoQ10) is a vitamin-like substance with strong antioxidant properties. The aim of this scientific study is to investigate the effects of CoQ10 on hypothyroidism at sera level with important biomarkers glial cell line-derived neurotrophic factor (GDNF), promyelocytic leukaemia zinc finger protein (PLZF), high mobility group box transcription factor 3 (SOX3) and thymocyte differentiation antigen 1 (THY1). Material and Methods: Four experimental animal groups were formed: Control group (n:7); hypothyroidism group (n:7); CoQ10 group (n:7); hypothyroidism + CoQ10 group (n:7). On the thirty-first day, sera of the animals were collected and Gdnf, Plzf, Sox3, Thy1 expression levels were analyzed in the blood. Results: Significant results occurred in all four biomarkers. As a final result, both hypothyroid pathology was associated with all biomarkers, and CoQ10 positively affected hypothyroidism. Conclusion: The effect of coenzyme Q10 on gene expression levels of Plzf, Gdnf, Thy1, Sox3 at sera level in rats with experimental hypothyroidism was shown by molecular analyses. Coenzyme Q10 regulates sera gene expression levels during treatment.