Isolation of 3-(Hydroxyacetyl)indole and Indole-3-carboxylic acid from Red Alga Halymenia durvillei: Their Anti-lung Cancer Cell and in vivo Anti-aging Activity

Author:

Manohong Preeyanuch1,Sornkaew Nilubon1,Meemon Krai2,Chumphoochai Kawita2,Sobhon Prasert2,Tamtin Montakan3,Sichaem Jirapast4,Mingvanish Withawat2,Srisuwannaket Choladda2,Mingvanish Withawat1,Niamnont Nakorn1ORCID

Affiliation:

1. Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand

2. Department of Anatomy, Faculty of Science, Mahidol University, Ratchathewi, Bangkok 10400, Thailand

3. Department of Fisheries, Coastal Aquatic Feed Research Institute, Coastal Fisheries Research and Development Bureau, Petchaburi, Thailand

4. Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang, Thailand

Abstract

This study aimed to evaluate the bioactivity and phytochemical investigation in red algae Halymenia durvillei. The polarity based solvent partition (hexane, ethyl acetate, butanol and water) of H. durvillei ethanolic crude were used for characterization. The present results of the ethyl acetate extract of red alga H. durvillei generated a 3-(hydroxyacetyl)indole (1), indole-3-carboxylic acid (2) as well as two fatty acids viz. palmitic acid (3) and α-linoleic acid (4). The viability against lung cancer cells of compounds 1 and 2 showed moderate activities against the A549 cell line with inhibition percentages of 12.97% and 25.81%, respectively. Analysis of the dose response of C. elegans anti-aging assay indicated that the survival rate of compound 1 was 12.62% while it was 11.04% for compound 2. Furthermore, H. durvillei isolation was used as an antioxidant, anti-cancer cell and anti-aging resource.

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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