Synthesis, Spectral Characterization and Antibacterial Activity of Copper(II) Complexes of Functionalized Hydrazones

Abstract

Copper(II) complexes having the formula CuL2 {where, L = 2-acetylthiophene acetoylhydrazone (ATAH), 2-acetylthiophene benzoylhydrazone (ATBH)} have been investigated on the basis of elemental analysis, molar conductivity measurements, magnetic susceptibility, UV-visible, IR and ESR spectral data. Non-electrolytic nature of the complexes are revealed by molar conductance data. IR spectral data suggested that hydrazones act as tridentate ligands. The spin Hamiltonian, orbital reduction and bonding parameters of complexes are calculated using ESR spectra of complexes. The compounds are screened for their antibacterial activities against Pseudomonas aureoginos and Bacillus cereus. Acetoylhydrazones show more antibacterial activity than the corresponding benzoyl hydrazones. Some of the Cu(II) complexes show more activity than hydrazone ligands.