Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone-Reference-Cited by-同舟云学术

Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone

Published:2021-10-30 Issue:5 Volume:37 Page:1125-1131
ISSN:2231-5039
Container-title:Oriental Journal Of Chemistry
language:en
Short-container-title:Orient. J. Chem

Author:

Nagamani Y.B.¹,Reddy K. Hussain²,Srinivasulu K.²,Dhanalakshmi D.²,Anuja K.²

Affiliation:

1. 2Department of Chemistry, Govt. Degree College (W), Hindupur, - 515201, India.

2. 1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu- 515 003, India.

Abstract

Metallo-hydrazones having the formula [M(IBAH)2] (where, M = Ni(II), Cu(II) and Zn(II); IBAH = p-Isopropylbenzaldehyde acetoylhydrazone) are prepared and confirmed on the basis of physico-chemical and spectral analyses. Conductivity data revealed that the complexes are non-electrolytes. Metal-DNA interactions are investigated using absorption spectrophotometry. Binding constant (Kb) data revealed that the copper complex interact DNA more strongly than other complexes. Antibacterial activity studies indicated higher activity for complexes than the metal free hydrazone ligand. The copper compound displays higher activity. DNA binding constants are correlated with the activity of metal compounds in this article.

Publisher

Oriental Scientific Publishing Company

Subject

Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry

Reference47 articles.

1. Raja, A.S.; Agarwal, A.K.; Mahajan, N.; Pandeya, S.N.; Ananthan, S. Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones., Indian J Chem., 2010, 49B(10), 1384–1388.

2. Rajitha, G.; Saideepa, N.; Praneetha, P. Synthesis and evaluation of N-(α-benzamidocinnamoyl) aryl hydrazone derivative for anti-inflammatory and antioxidant activities., Indian J Chem., 2011, 50B, 729–33.

3. CrossRef

4. Tian, B.; He, M.; Tang, S.; Hewlett, I.; Tan, Z.; Li, J. et al. Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein., Bioorg Med Chem Lett., 2009, 19, 2162–2167.

5. CrossRef