Affiliation:
1. P.G. & Research Department of Chemistry, Rajeshwari Vedhachalam Government Arts College, Chengalpattu-603001, India
Abstract
Diversely functionalized chromeno-pyrimidine-2,5-dione/thione compounds were synthesized by
cyclocondensation of 4-hydroxy coumarin, aldehydes and urea/thiourea using tannic acid as a green
catalyst and 1:1 (EtOH:H2O) as a green solvent. Different acids were screened for their catalytic
activity of chromeno-pyrimidine-2,5-dione/thione derivatives. Tannic acid (10 mol%) was used as a
suitable catalyst with increased catalytic activity. By utilizing this protocol, chromeno-pyrimidine
scaffolds were prepared in acceptable to excellent yield without the use of conventional volatile organic
solvent and toxic metal catalyst. To our best of knowledge, this is the first report, in which tannic acid
is utilized successfully as an eco-safe catalyst for synthesis of fused pyrimidines.
Publisher
Asian Journal of Chemistry
Cited by
6 articles.
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