Bi‐tailed N‐cationic surfactant promoted green synthesis of 2‐amino‐5‐oxo‐4‐alkyl‐4,5‐dihydropyrano[3,2‐c]chromene‐3‐carbonitrile derivatives via multicomponent reaction

Abstract

AbstractDiversely functionalized 2‐amino‐5‐oxo‐4‐alkyl‐4,5‐dihydropyrano[3,2‐c]chromene‐3‐carbonitrile derivatives were synthesized from substituted aromatic aldehydes, 4‐hydroxy coumarin and malononitrile using benzethonium chloride as an easily available, less explored green catalyst and 1:4 (EtOH:H2O) as a green solvent via multicomponent reaction. All the products were thoroughly characterized by infrared (IR), 1H‐NMR, 13C‐NMR, and mass spectral analyses. Synthesized compounds were screened rule of five for drug‐likeness and green matrix properties.