Affiliation:
1. Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University, Arcadia Grant, Premnagar, Dehradun-248007, India
2. The Himalaya Drug Company, Saharanpur Road, Clement Town, Dehradun-248002 India
Abstract
In present study, free radical scavenging activity of methanolic extract of all parts (leaves, seeds, root,
stem and flower) of Perilla frutescens L. has been estimated. The promising results, among the five
plant parts leaves, seeds, root, stem, flower and the standard tested for the in vitro antioxidant activity
using the DPPH method, the crude methanolic extracts of all parts showed antioxidant activity, with
IC50 values of 5.95 ± 0.10, 8.28 ± 0.20, 66.27 ± 0.17, 80.03 ± 0.10 and 122.35 ± 0.17 μg/mL, respectively.
The IC50 value for ascorbic acid was 5.19 ± 0.26 μg/mL. While butylated hydroxyl toluene (BHT) a
synthetic commercial antioxidant has comparatively high IC50 value of 108.46 ± 0.57 μg/mL. Presence
of zinc in all parts of plant in the range 17.20 ± 0.22 to 33.56 ± 0.32 ppm further supports the strong
antioxidant activity of Perilla frutescens L. The phytochemical tests indicated that all parts of Perilla
frutescens L. have considerable proportion of important phytochemicals and are in rich source of
secondary metabolites like polyphenols, tannins, alkaloids and flavonoids. Several of such compounds
are known to possess potent antioxidant activity.
Publisher
Asian Journal of Chemistry