ALLETHRIN INDUCED TOXICOPATHOLOGICAL ALTERATIONS IN ADULT MALE ALBINO RATS

Abstract

This study was designed to investigate the allethrin induced toxico-pathological changes in adult male albino rats. A total of 60 adult male albino rats were divided randomly into 4 equal groups. Group A was treated as control while group B was given Allethrin @ 0.5g/kg, group C @ 1.0g/kg and group D @1.5g/kg body weight respectively, orally once at day 14 of experiment. Dullness, erected hairs, alopecia, less response towards feed and water, watery droppings, tremors, convulsions and coma were more prominent signs in treated groups. Feed intake and body weight was decreased in all treated groups. Acute mortality was seen in group C and D. The total erythrocyte and leukocyte count, hemoglobin concentration and packed cell volume (P≤0.05) was deviated from normal in all the groups treated with allethrin. Histopathologically, kidneys exhibited condensed nuclei, necrotic tubules and congested renal parenchyma. In liver, vacuolar degeneration in nucleus and cytoplasm was observed. Micro nucleated lymphocytes were also evident in group D treated with highest dose of allethrin. In conclusion, allethrin induced dose and time-dependent toxico-pathological effects in adult male albino rats were observed and presented.