Are improper kinetic models hampering drug development?-Reference-Cited by-同舟云学术

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Are improper kinetic models hampering drug development?

Published:2014-10-28 Issue: Volume:2 Page:e649
ISSN:2167-8359
Container-title:PeerJ
language:en
Short-container-title:

Author:

Walsh Ryan¹

Affiliation:

1. Department of Chemistry, Carleton University, Ottawa, ON, Canada

Publisher

PeerJ

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://peerj.com/articles/649.pdf

Reference20 articles.

1. A new roadmap for drug development for Alzheimer’s disease;Becker;Nature Reviews Drug Discovery,2014

2. Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system;Bernett;The Journal of Biological Chemistry,2002

3. The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression;Burton;The Journal of Biological Chemistry,2008

4. Examples of anti-competitive inhibition;Dodgson;Nature,1956

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1. Lipid- and substrate-induced conformational and dynamic changes in a glycosyltransferase involved in E. coli LPS synthesis revealed by 19F and 31P NMR;Biochimica et Biophysica Acta (BBA) - Biomembranes;2023-12

2. Engineered repeat proteins as scaffolds to assemble multi-enzyme systems for efficient cell-free biosynthesis;Nature Communications;2023-05-04

3. The Binding of Different Substrate Molecules at the Docking Site and the Active Site of γ-Secretase Can Trigger Toxic Events in Sporadic and Familial Alzheimer’s Disease;International Journal of Molecular Sciences;2023-01-17

4. Models of enzyme inhibition and apparent dissociation constants from kinetic analysis to study the differential inhibition of aldose reductase;Journal of Enzyme Inhibition and Medicinal Chemistry;2022-05-24

5. Binding of different substrate molecules at the docking site and the active site of γ-secretase can trigger toxic events in sporadic and familial Alzheimer’s disease;2022-04-13

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