The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression-Reference-Cited by-同舟云学术

The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression

Published:2008-08 Issue:34 Volume:283 Page:22992-23003
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Burton Catherine R.,Meredith Jere E.,Barten Donna M.,Goldstein Margi E.,Krause Carol M.,Kieras Cathy J.,Sisk Lisa,Iben Lawrence G.,Polson Craig,Thompson Mark W.,Lin Xu-Alan,Corsa Jason,Fiedler Tracey,Pierdomenico Maria,Cao Yang,Roach Arthur H.,Cantone Joseph L.,Ford Michael J.,Drexler Dieter M.,Olson Richard E.,Yang Michael G.,Bergstrom Carl P.,McElhone Kate E.,Bronson Joanne J.,Macor John E.,Blat Yuval,Grafstrom Robert H.,Stern Andrew M.,Seiffert Dietmar A.,Zaczek Robert,Albright Charles F.,Toyn Jeremy H.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference53 articles.

1. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2. Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics

3. Evidence that the 42- and 40-amino acid forms of amyloid protein are generated from the -amyloid precursor protein by different protease activities

4. The Carboxyl Termini of β-Amyloid Peptides 1-40 and 1-42 Are Generated by Distinct γ-Secretase Activities

5. Rank-Order of Potencies for Inhibition of the Secretion of Aβ40 and Aβ42 Suggests That Both Are Generated by a Single γ-Secretase

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