Comparison in antioxidant and antitumor activities of pine polyphenols and its seven biotransformation extracts by fungi

Abstract

Microbial transformation can strengthen the antioxidant and antitumor activities of polyphenols. Polyphenols contents, antioxidant and antitumor activities of pine polyphenols and its biotransformation extracts byAspergillus niger,Aspergillus oryzae,Aspergillus carbonarius,Aspergillus candidus,Trichodermas viride, Mucor wutungkiaoand Rhizopus spwere studied. Significant differences were noted in antioxidant and antitumor activities. The highest antioxidant activities in Trolox equivalent antioxidant capacity (TEAC), DPPH radical scavenging activity, superoxide anion radical scavenging activity, hydroxyl radical scavenging activity, reducing power assay and antitumor activity against LoVo cells were biotransformation extract ofAspergillus carbonarius(BAC), biotransformation extract ofMucor wutungkiao(BMW), biotransformation extract ofAspergillus carbonarius(BAC), biotransformation extract ofAspergillus niger(BAN), biotransformation extract ofAspergillus oryzae(BAO) and BMW, respectively. Correlation analysis found that antioxidant and antitumor activities were associated with polyphenols contents and types of free radicals and tumors.A. carbonariuscan make polyphenol oxidation, hydroxylation and methylation, and form new polyphenols. In conclusion,A. carbonarius,A. niger and M. wutungkiaoare valuable microorganisms used for polyphenols biotransformation and enhance the antioxidant and antitumor activities of polyphenols.