Salvianolic acid B plays an anti-obesity role in high fat diet-induced obese mice by regulating the expression of mRNA, circRNA, and lncRNA

Author:

An Tian1,Zhang Jing2,Lv Bohan1,Liu Yufei3,Huang Jiangpinghao4,Lian Juan1,Wu Yanxiang1,Gao Sihua1,Jiang Guangjian1

Affiliation:

1. Traditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing, China

2. Department of Endocrinology, Tangshan Workers Hospital, Tangshan, China

3. The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China

4. University of Southern California, Los Angeles, CA, USA

Abstract

Background Adipose tissue plays a central role in obesity-related metabolic diseases such as type 2 diabetes. Salvianolic acid B (Sal B), a water-soluble ingredient derived from Salvia miltiorrhiza, has been shown to reduce obesity and obesity-related metabolic diseases by suppressing adipogenesis. However, the role of Sal B in white adipose tissue (WAT) is not yet clear. Methods Illumina Hiseq 4000 was used to study the effects of Sal B on the expression of long non-coding RNA (lncRNA) and circular RNA (circRNA) in epididymal white adipose tissue induced by a high fat diet in obese mice. Results RNA-Seq data showed that 234 lncRNAs, 19 circRNAs, and 132 mRNAs were differentially expressed in WAT under Sal B treatment. The up-regulated protein-coding genes in WAT of the Sal B-treated group were involved in the insulin resistance pathway, while the down-regulated genes mainly participated in the IL-17 signaling pathway. Other pathways may play an important role in the formation and differentiation of adipose tissue, such as B cell receptor signaling. Analysis of the lncRNA–mRNA network provides potential targets for lncRNAs in energy metabolism. We speculate that Sal B may serve as a potential therapeutic approach for obesity.

Funder

National Natural Science Foundation of China

Beijing Municipal Education Commission scientific research and graduate training to build projects

Tangshan Science and Technology Innovation Team Training Program

Chaoyang District Collaborative Innovation Project

Horizontal subject of Zhong Fu Boai Health management (Beijing) Co., Ltd

Publisher

PeerJ

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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