Longterm treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage-Reference-Cited by-同舟云学术

Longterm treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage

Published:1999-12 Issue:12 Volume:18 Page:738-739
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Raschka C¹,Koch H J²

Affiliation:

1. General Hospital Fulda, Medical Department, Pacelliallee 4, 36043 Fulda, Germany

2. University Clinic of Psychiatry, Universitdtsstrasse 84, D-93053 Regensburg, Germany

Abstract

Fumaric acid preparations are used as longterm and effective treatment of psoriasis. Apart from gastrointestinal, dermatological and hematological side-effects, transient renal damage was observed during treatment with fumaric acid. The case of a 38 year old woman who was treated with fumaric acid (420 mg bid) for 5 years before she complained of fatigue and weakness. According to clinical laboratory she had developed severe proximal tubular damage. Hypophosphatemia, glycosuria and proteinuria persisted although medication was stopped immediately.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1191/096032799678839662

Reference7 articles.

1. Systemic therapy with fumaric acid derivates: New possibilities in the treatment of psoriasis

2. Fumars�uremono�thylester: Wirkung auf DNA-synthese und erste tierexperimentelle befunde

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