Development of a novel pink-eyed dilution mouse model showing progressive darkening of the eyes and coat hair with aging

Author:

ISHIKAWA Akira1,SUGIYAMA Makoto23,HONDO Eiichi3,KINOSHITA Keiji1,YAMAGISHI Yuki1

Affiliation:

1. Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan

2. Present address: Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Kitasato University, Higashi, Towada, Aomori 034-8628, Japan

3. Laboratory of Animal Morphology and Function, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan

Publisher

Japanese Association for Laboratory Animal Science

Subject

General Veterinary,General Biochemistry, Genetics and Molecular Biology,Animal Science and Zoology,General Medicine

Reference30 articles.

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2. 2. Ancans J., Tobin D.J., Hoogduijn M.J., Smit N.P., Wakamatsu K., and Thody A.J. 2001. Melanosomal pH controls rate of melanogenesis, eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells. Exp. Cell Res. 268: 26–35.

3. 3. Boissy R.E. and Hornyak T.J. 2006. Extracutaneous melanocytes. pp. 91–107. In: The Pigmentary System: Physiology and Pathophysiology, 2nd ed. (Nordlund, J.J., Boissy, R.E., Hearing, V.J., King, R.A., Oetting, W.S., and Ortonne, J.-P. eds.), Blackwell Publishing, Massachusetts.

4. 4. Brilliant M.H., Ching A., Nakatsu Y., and Eicher E.M. 1994. The original pink-eyed dilution mutation (p) arose in Asiatic mice: implications for the H4 minor histocompatibility antigen, Myod1 regulation and the origin of inbred strains. Genetics 138: 203–211.

5. 5. Eiberg H., Troelsen J., Nielsen M., Mikkelsen A., Mengel-From J., Kjaer K.W., and Hansen L. 2008. Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression. Hum. Genet. 123: 177–187.

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