The present paper investigates convection in a Casson nanofluid layer in porous medium under the influence of Coriolis force using Darcy-Brinkman model. The analysis is carried out using linear stability theory, normal mode technique, and one term Galerkin type weighted residual method for various metallic and non-metallic nanoparticles. The outcomes are compared with previously published results, and fine agreements are noted for the permissible range of parameters. Numerical simulation for porous media is carried out for blood (Casson fluid) using the software Mathematica to make the investigation helpful for practical applications. The effect of porous medium, rotation, Casson parameter, and nanoparticle parameters is discussed. Interestingly, it is found that though Casson fluids are more stable as compared to regular fluids, the Casson parameter itself has a destabilizing effect on the system. The main objective of the study is to consider the impact of Coriolis force on a Casson nanofluid layer with metallic and non-metallic nanoparticles. This effect is of paramount importance in geophysical studies, particularly in the extraction of crude oils. Further, by increasing the rotation parameter, the axial velocity of the blood-based Casson fluid increases, which may help in the treatment of stenosis of arteries and throat. The importance and novelty of the study is the fact that Coriolis force can stabilize various nanoparticle-based Casson fluid layer systems, which were otherwise unstable. As far as metallic and non-metallic nanoparticles are concerned, the stability pattern followed by metallic nanofluids is iron-blood > copper-blood > silver-blood > gold-blood, and for non-metallic nanofluids is silica-blood > alumina-blood > titanium oxide-blood > copper oxide-blood.