Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity

Author:

Marra Pedro S.12,Yamanashi Takehiko13,Crutchley Kaitlyn J.124,Wahba Nadia E.25,Anderson Zoe-Ella M.2,Modukuri Manisha2,Chang Gloria2,Tran Tammy2,Iwata Masaaki3,Cho Hyunkeun Ryan6,Shinozaki Gen12

Affiliation:

1. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA

2. Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA

3. Department of Neuropsychiatry, Tottori University Faculty of Medicine, Yonago-shi, Tottori 680-8550, Japan

4. University of Nebraska Medical Center College of Medicine, Omaha, NE 68131, USA

5. Department of Psychiatry, Oregon Health and Science University School of Medicine, Portland, OR 97239, USA

6. Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA 52242, USA

Publisher

Impact Journals, LLC

Subject

Cell Biology,Aging

Reference58 articles.

1. Older People Projected to Outnumber Children for First Time in U.S. History. United States Census Bureau. 2018. https://www.census.gov/newsroom/press-releases/2018/cb18-41-population-projections.html (11/7/2021).

2. Metformin as a Tool to Target Aging.;Espeland;Cell Metab,2016

3. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.;Partridge;Cell Metab,2010

4. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.;Beyer;Elife,2016

5. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.;Sinclair;Nature,2003

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