PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas

Author:

Czyż Małgorzata1,Toma Monika2,Gajos-Michniewicz Anna1,Majchrzak Kinga1,Hoser Grazyna3,Szemraj Janusz4,Nieborowska-Skorska Margaret5,Cheng Phil6,Gritsyuk Daniel5,Levesque Mitchell6,Dummer Reinhard6,Sliwinski Tomasz2,Skorski Tomasz5

Affiliation:

1. Department of Molecular Biology of Cancer, Medical University of Lodz, 92-215 Lodz, Poland

2. Department of Molecular Genetics, University of Lodz, 90-236 Lodz, Poland

3. Department of Flow Cytometry, Medical Center for Postgraduate Education, 01-813 Warsaw, Poland

4. Department of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland

5. Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA

6. Department of Dermatology, Faculty of Medicine, University Hospital Zürich, and University of Zürich, CH-8952, Zürich, Switzerland

Publisher

Impact Journals, LLC

Subject

Oncology

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