Xenotransplantation of pediatric low grade gliomas confirms the enrichment of BRAF V600E mutation and preservation of CDKN2A deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma

Author:

Kogiso Mari1,Qi Lin1,Lindsay Holly1,Huang Yulun12,Zhao Xiumei13,Liu Zhigang14,Braun Frank K.1,Du Yuchen1,Zhang Huiyuan1,Bae Goeun5,Zhao Sibo1,Injac Sarah G.1,Sobieski Mary5,Brunell David5,Mehta Vidya6,Tran Diep6,Murray Jeffrey7,Baxter Patricia A.1,Yuan Xiao-Jun8,Su Jack M.1,Adesina Adekunle6,Perlaky Laszlo1,Chintagumpala Murali1,Parsons D. Williams1,Lau Ching C.1,Stephan Clifford C.5,Lu Xinyan9,Li Xiao-Nan1

Affiliation:

1. Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX, USA

2. Department of Neurosurgery, The First Affiliated Hospital, Soochow University, Suzhou, China

3. Department of Ophthalmology, First Affiliated Hospital of Harbin, Medical University, Harbin, China

4. Department of Radiotherapy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China

5. Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M College of Medicine, Houston, TX, USA

6. Department of Pathology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA

7. Department of Hematology and Oncology, Cook Children's Medical Center, Fort Worth, TX, USA

8. Department of Hematology and Oncology, Xinhua Children's Hospital, Shanghai, China

9. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Publisher

Impact Journals, LLC

Subject

Oncology

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