Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

Author:

Davis Nicole M.1,Sokolosky Melissa1,Stadelman Kristin1,Abrams Stephen L.1,Libra Massimo2,Candido Saverio2,Nicoletti Ferdinando2,Polesel Jerry3,Maestro Roberta4,D’Assoro Antonino5,Drobot Lyudmyla6,Rakus Dariusz7,Gizak Agnieszka7,Laidler Piotr8,Dulińska-Litewka Joanna8,Basecke Joerg9,Mijatovic Sanja10,Maksimovic-Ivanic Danijela10,Montalto Giuseppe1112,Cervello Melchiorre12,Fitzgerald Timothy L.13,Demidenko Zoya N.14,Martelli Alberto M.15,Cocco Lucio15,Steelman Linda S.1,McCubrey James A.1

Affiliation:

1. Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA

2. Department of Bio-Medical Sciences, University of Catania, Catania, Italy

3. Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy

4. Experimental Oncology 1, CRO IRCCS, National Cancer Institute, Aviano, Pordenone, Italy

5. Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA

6. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine

7. Department of Animal Molecular Physiology, Institute of Experimental Biology, Wroclaw University, Wroclaw, Poland

8. Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland

9. Department of Medicine University of Göttingen, Göttingen, Germany

10. Department of Immunology, Institute for Biological Research “Sinisa Stankovic” University of Belgrade, Belgrade, Serbia

11. Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy

12. Consiglio Nazionale delle Ricerche,Istituto di Biomedicina e Immunologia Molecolare “Alberto Monroy”, Palermo, Italy

13. Department of Surgery, Brody School of Medicine at East Carolina University, Greenville, NC

14. Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA

15. Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy

Publisher

Impact Journals, LLC

Subject

Oncology

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