As expected, based on rapamycin-like p53-mediated gerosuppression, mTOR inhibition acts as a checkpoint in p53-mediated tumor suppression
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Published:2022-08-30
Issue:
Volume:9
Page:38-41
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ISSN:2331-4737
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Container-title:Oncoscience
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language:en
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Short-container-title:Oncoscience
Author:
Blagosklonny Mikhail V.
Publisher
Impact Journals, LLC
Subject
Cancer Research,Oncology
Reference22 articles.
1. Kon N, Ou Y, Wang SJ, Li H, Rustgi AK, Gu W. mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression. Genes Dev. 2021; 35: 59-64. https://doi.org/10.1101/gad.340919.120. PMID:33303641
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3. Li T, Kon N, Jiang L, Tan M, Ludwig T, Zhao Y, Baer R, Gu W. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell. 2012; 149: 1269-1283. https://doi.org/10.1016/j.cell.2012.04.026. PMID:22682249
4. Blagosklonny MV. Cell senescence, rapamycin and hyperfunction theory of aging. Cell Cycle. 2022; 21: 1456-1467. https://doi.org/10.1080/15384101.2022.2054636. PMID:35358003
5. Demidenko ZN, Korotchkina LG, Gudkov AV, Blagosklonny MV. Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci U S A. 2010; 107: 9660-9664. https://doi.org/10.1073/pnas.1002298107. PMID:20457898