Development of Molecularly Imprinted Quartz Crystal Microbalance (QCM) Sensor Including Two-Dimensional Hexagonal Boron Nitride (2D-hBN) Nanosheets and its Application to Ascorbic Acid Detection

Abstract

A new quartz crystal microbalance (QCM) sensor based on two-dimensional hexagonal boron nitride (2D-hBN) nanosheets including molecular imprinted polymers (MIP) was formed for ascorbic acid (AA) sensing. Some characterization methods such as X-ray diffraction (XRD), scanning electron microscopy (SEM), fourier-transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were performed for characterizations of sensor structure. After formation of AA imprinted QCM chip, AA imprinted QCM sensor showed high sensing performance and linear range of 1.00 × 10−10–1.00 × 10−7 M and detection limit (LOD) of 3.0 × 10−11 M were obtained. Finally, AA imprinted sensor was applied to plasma samples for AA analysis.