A Highly Sensitive Electrochemical Sensor Based on β-cyclodextrin Functionalized Multi-Wall Carbon Nanotubes and Fe3O4 Nanoparticles for Rutin Detection

Abstract

A functionalized nanocomposites composed of multi-wall carbon nanotubes (MWCNTs), Fe3O4 nanoparticles (Fe3O4) and β-cyclodextrin (CD) was prepared. The MWCNTs-CD-Fe3O4 modified glassy carbon electrode (GCE) displayed good electrochemical response towards rutin (Ru). The detection linear range and the detection limit of the electrochemical sensor for Ru were 0.02–10 μM and 16.4 nM, respectively. The results of actual sample detection were consistent with those of ultra-high performance liquid chromatography (UHPLC). The modified materials were also analyzed by UV-visible spectroscopy (UV-Vis)，transmission electrode microscope (TEM), and electrochemical impedance spectroscopy (EIS), respectively. The prepared nanocomposites integrate the excellent electric conductivity and electrocatalytic activity of MWCNTs and Fe3O4, as well as the disperse ability of CD, and may play a synergistic role in the electrochemical response of the modified electrode towards Ru. Moreover, the prepared sensor had good anti-interference ability and potential application in the actual content detection of drugs.