Electrochemical Determination of Famotidine in Real Samples Using rGO/Cu2O Nanocomposite Modified Carbon Paste Electrode

Abstract

Here, we have developed a sensitive electrochemical sensor for famotidine (FAT) using Cu2O nanoparticles and reduced graphene oxide (rGO). The Cu2O nanoparticles and rGO were synthesized through a simple process and characterized by versatile analytical techniques. The prepared Cu2O nanoparticles and rGO were taken to modify the carbon paste electrode (Cu2O/rGO/CPE) and applied for the electrochemical analysis of the FAT at pH 6.0. Cu2O/rGO/CPE showed superior response to determine FAT, attributed to the high surface area of rGO and the electrocatalytic properties of Cu2O nanoparticles. The designed FAT sensor exhibited two dynamic linear ranges from 0.1–3.0 μM and 3.0–50.0 μM with a limit of detection of 0.08 μM (S/N = 3) using a differential pulse voltammetry. The proposed sensor also showed a repeatable and stable response over one month with negligible interference from usual organic and inorganic species. The sensor was also validated to measure FAT in real samples (urine, serum and pharmaceutical tablet) with good recoveries from 99.6 to 110.9%.